Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Molecular Formula
- C42H60K2O16
- CAS No.
- 68797-35-3
- EC No.
- 272-296-1
- Technologies
- Product Families
- Molecular Structure
Features & Benefits
- Benefit Claims
- Labeling Claims
- Benefits
- Whitening - Inhibits active oxygen formation: Dipotassium Glycyrrhizinate is a flavonoid compound with strong antioxidant activity. Experimental study uses superoxide dismutase SOD as a control group, and the result shows that Dipotassium Glycyrrhizinate can effectively inhibit the production of active oxyge. 2) Inhibits tyrosinase: The IC50 of tyrosinase of Dipotassium Glycyrrhizinate is very low compared to the commonly used whitening ingredient. Dipotassium Glycyrrhizinate is a well-recognized strong tyrosinase inhibitor; it is more effective than some commonly used whitening agents. 3) Inhibits melanin production: Test selects the back skin of guinea pigs under UVB irradiation. The result indicates that white coefficient of skin pretreated with 0.5% Dipotassium Glycyrrhizinate is higher than that of the control group’s skin, and the effect is obvious. Thus Dipotassium Glycyrrhizinate has a significant inhibitory effect on melanin formation. It can be used to prevent skin pigmentation and melanin production after sun exposure.
- Anti-inflammation - The result of mouse ear swelling test shows that toothpaste containing Dipotassium Glycyrrhizinate can significantly inhibit xylene-induced ear swelling of mouse. So it has a strong anti-inflammatory effect for acute inflammation. The in vitro anti-inflammatory experiment of Dipotassium Glycyrrhizinate suggests that in a certain concentration range, Dipotassium Glycyrrhizinate inhibits cells from secreting inflammatory mediator NO and inflammatory cytokine IL-6, when it acts on LPS to stimulate RAW264.7 cells. And its inhibition function depends on a certain dosage. Therefore, Dipotassium Glycyrrhizinate has obvious anti-inflammatory activity in vitro
- Characteristics
- Plamed owns a foreign planting base, which ensures a stable supply;
- Through optimizing the process, a complete and thorough reaction is carried out;
- Plamed adopts Korean cosmetic standard that is more applicable to cosmetics raw material.
Applications & Uses
- Markets
- Hair Care Applications
- Oral Care Applications
- Skin Care Applications
- Sun Care Applications
- Source
Licorice (Scientific name: Glycyrrhiza uralensis Fisch) belongs to leguminosae herbaceous perennial. It is also a traditional Chinese herb plant. Licorice mainly grows in arid, semi-arid sandy soil, desert edge and loess hilly area. Most of wild licorice in China is distributed in Sinkiang, Inner Mongolia, Ningxia, Gansu, Shanxi, and other places. There are a large number of artificial cultivation licorice areas in Sinkiang, Gansu, Inner Mongolia and Ningxia provinces. Licorice contains a variety of effective chemical components, such as liquiritin, glycyrrhizic acid, glycyrrhetinic acid, licorice flavonoids, liquiritigenin, etc. These components are mainly found in licorice root and bark. So the thick roots of licorice are major medicinal source commonly. Licorice extract is mainly used in the pharmaceutical, health care and cosmetics industries.
Properties
- Appearance
- White or Yellowish powder
- Physical Properties
- Typical Properties
- Microbiological Values
- Heavy Metals
| Value | Units | Test Method / Conditions | |
| Particle size (through 80 mesh) | 98 | % | - |
| Loss on drying | max. 8.00 | % | - |
| Residue on ignition | 18.00~22.00% | % | - |
| Arsenic salt | max. 2 | ppm | - |
| Chloride | max. 0.014 | % | - |
| Sulfate | max. 0.029 | % | - |
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 899.12 | g/mol | - |
| Specification (UV) | 98 | % | - |
| Content (UV) | min. 98.0 | % | - |
| Content (HPLC) | min. 70.0 | % | - |
| Clarity | Clarification | - | - |
| PH Value | 5.0~6.0 | - | - |
| Value | Units | Test Method / Conditions | |
| Total plate count | max. 1000 | cfu/g | - |
| Yeast & mold | max. 100 | cfu/g | - |
| E. coli | Negative | - | - |
| Staphylococcus | Negative | - | - |
| Salmonella | Negative | /10g |
| Value | Units | Test Method / Conditions | |
| Heavy metals | max. 10 | ppm | - |
| Arsenic | max. 2 | ppm | - |
| Plumbum | max. 2 | ppm | - |
Technical Details & Test Data
- Manufacturer Process Flow Chart
Safety & Health
- Safety
- The FDA includes Dipotassium Glycyrrhizinate on the list of Generally Recognized As Safe (GRAS). It can be directly used as food additives.
- EU Cosmetics Directives and the Cosmetic Ingredient Review (CIR) Expert Panel both believe that Dipotassium Glycyrrhizinate is non-toxic and safe when used in OTC personal care products.
- Clinical trial shows that Dipotassium Glycyrrhizate doesn’t penetrate nor irritate the skin.
Packaging & Availability
- Packaging
- Packed in 25kg paper drums with two plastic bags inside.
- Minimal Package - 10G
- Minimal Order Quantity - 10G
Storage & Handling
- Storage
Stored in a cool dry place and away from direct sunlight and oxidizing agents.