Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- INCI Name
- Ingredient Origin
- Vitamin Type
- Cosmetic Ingredients Functions
- Molecular Formula
- C6H6Na3O9P
- Identification
- IR(Infrared Ray)
- CAS No.
- 66170-10-3
- EC No.
- 425-180-1
- Technologies
- Product Families
- Molecular Structure
Features & Benefits
- Benefit Claims
- Benefits
- Anti-aging - Sodium Ascorbyl Phosphate is an effective oxygen free radical scavenger. It protects skin from UV rays, and enhances photo-protective property of sunscreens. Moreover, it is more effective in combination with vitamin E or vitamin E derivatives. Also SAP has some improvement on facial wrinkles and fine lines.
- Whitening skin - Experiments have shown that 2% Sodium Ascorbyl Phosphate in cosmetics can significantly reduce pigmentation, and whiten skin. It has no irritating effect on skin. This is because SAP is absorbed by skin and then hydrolyzed to vitamin C. Thereby it can decrease melanin formation, and inhibit pigmentation. Then SAP can exert effect of whitening skin and removing freckle.
- Acne treatment - In an in vitro study, a moderate concentration of 1% sodium ascorbyl phosphate shows a strong antibacterial effect on acne. In addition, in a study of 76.9% of patients with facial acne, the use of 5% sodium ascorbyl phosphate is significantly better than other acne treatments after 12 weeks. It has no side effects. In addition, other clinical studies have shown that SAP is more effective in treating acne than 5% benzoyl peroxide, 1% phosphate clindamycin, and 0.1% adapalene.
- Advantages
Compared with vitamin C
- Vitamin C is a catalyst in cell oxidation-reduction reaction. Human body cannot synthesize itself. Vitamin C must be taken from food. High activity is the advantage of vitamin C, but at the same time it is the inadequacy, mainly as follows: (1) unstable, susceptible to light, heat, etc. The reduction ability of vitamin C will be lost after decomposition. Expose vitamin C at room temperature for one day, the loss is more than 50%; and it decomposes faster under high temperature or light. (2) It is easily dehydrated and loses its activity in an acidic medium at high temperature.
- The activity of vitamin C is mainly derived from two hydroxyl groups on its enol structure. If any of its hydroxyl groups are esterified with mineral acid, the stability to heat, acid and oxygen will greatly enhance. For example, the antioxidant capacity of phosphate derivatives of vitamin C in boiling water is about 10 times that of vitamin C. Compared with vitamin C, Sodium Ascorbyl Phosphate (1) is chemically stable and difficult to be oxidized; (2) has high thermal stability; (3) has high bioavailability, and can also be decomposed by phosphatase in human body. It has same effects as vitamin C.
Comparison with other vitamin C derivatives
- Common vitamin C derivatives include vitamin C metal salts, vitamin C phosphates, vitamin C sulfates, and vitamin C palmitate.
- Although vitamin C metal salt is simple and easy to obtain, it is not stable due to easy moisture absorption. Studies have found that vitamin C sulfate cannot be absorbed by body. The palmitate resources required for vitamin C palmitate are not abundant, and it is not suitable for large-scale production. The shortcomings of vitamin C phosphate magnesium in industrial production and application are mainly as follows: the crystallization yield is low; and it is difficult to separate from by-products produced by the reaction; the dissolution rate in water is very low; and it is easy to change color after being placed.
- Sodium Ascorbyl Phosphate overcomes the shortcomings of the above vitamin C derivatives. It has high stability and good water solubility. It can be decomposed and utilized by phosphatase in human body. Also it is suitable for large-scale production.
Applications & Uses
- Markets
- Skin Care Applications
- Treatment Product Applications
- Source
Currently, there are two methods for the synthesis of Sodium Ascorbyl Phosphate: chemical synthesis (group protection method and direct acylation method) and microbial synthesis (biological fermentation method).
Direct acylation Group protection Process Vitamin C and sodium hydroxide solution are esterified under the action of enzyme produced by microorganisms. And then post-treated to obtain Sodium Ascorbyl Phosphate. Vitamin C is acylated in pyridine and water system. The protecting group is removed under acidic conditions. And then neutralize with alkali to obtain Sodium Ascorbyl Phosphate. Advantage Less by-products; less pollution to environment. / Disadvantage / Complex reaction process. After the reaction, there are many residual by-products that are difficult to remove.
Properties
- Appearance
- White or pale yellowish powder
- Physical Properties
- Typical Properties
- Heavy Metals
| Value | Units | Test Method / Conditions | |
| Vitamin C content | min. 45 | % | — |
| Loss on drying | max. 11.0 | % | — |
| pH (3% aqueous solution) | 8.00–11.0 | — | — |
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 322.05 | g/mol | — |
| Specification | 98 | % | — |
| Sodium Ascorbyl Phosphate | 98% | — | — |
| Assay | min. 98 | % | — |
| Value | Units | Test Method / Conditions | |
| Heavy Metals | max. 20 | ppm | — |
| As | max. 2 | ppm | — |
Technical Details & Test Data
- Manufacturer Flow Chart
Safety & Health
- Safety
- The CIR Expert Panel has experimentally concluded that sodium ascorbyl phosphate is safe for use in cosmetics;
- According to Australian National Industrial Chemicals Notification and Assessment Scheme, the maximum concentration of sodium ascorbyl phosphate in most cosmetic formulations is 5%; and the maximum concentration in sunscreen products is 1%. Otherwise it causes side effect such as skin irritation.
- Sodium Ascorbyl Phosphate has been included in The Catalog Of the International Cosmetics Raw Material Standard Chinese Name issued by Food and Drug Administration in 2010.
Packaging & Availability
- Packaging
- Packed in 25kg paper drums with two plastic bags inside.
- Minimal Package - 10G
- Minimal Order Quantity - 10G
Storage & Handling
- Storage
Stored in a cool dry place and away from direct sunlight and oxidizing agents.