Brands

Shin-Etsu Chemical Co., Ltd. began to produce water soluble cellulose ethers in 1962, with the trade name METOLOSE®. METOLOSE® consists of Methylcellulose (methylcellulose USP) and three substitution types of Hydroxypropylmethylcellulose (Hypromellose USP) each available in several grades differing in viscosity. METOLOSE® can be used as a binder for solid dosage forms such as tablets and granules. It also provides a variety of functions such as water retention, thickening, protective colloid, surface activity, etc. It also can be used as a hydrophilic matrix agent. The hydrophilic matrix system is the simplest sustained release technology for oral dosage forms, consisting essentially of a drug and a water soluble highly viscous polymer. Recent advances in this hydrophilic matrix system have allowed more controllable and reproducible drug release by controlling the chemical and physical properties of the polymer. METOLOSE® SR is especially suitable for this application, and provides a genuine consistency in the final products.

TYLOPUR® is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations. In addition, TYLOPUR® is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

TYLOPUR Xtend Nutra® is a plant derived ingredient (high viscous hydroxypropyl methylcellulose, HPMC) that has been developed by Shin-Etsu to provide a controlled, extended release of active compounds over a longer period of time, prolonging their effects on human body. TYLOPUR Xtend Nutra® acts as a hydrophilic matrix agent in hydrophilic matrix system, which is the simplest sustained release technology, consisting essentially of an active compound and a water soluble highly viscous natural polymer. Such a system allows a simple and straight forward direct compression formulation and a reduction of doses per day. It is not only cost effective but it is also consumer friendly. The mechanism of action of TYLOPUR Xtend Nutra® in hydrophilic matrix tablets consists of initial swelling caused by the hydration of a tablet, protective gel formation, which regulates the degree of active compound’s release, and time-related extended release of an active compound through the gel layer.

TYLOPUR ClearCoat Nutra® is a plant derived, water soluble ingredient (low viscous hydroxypropyl methylcellulose, HPMC) that has been developed by Shin-Etsu as a natural and easy-to-use material for film coating of nutraceutical and nutritional supplement tablets. It can be quickly dissolved in water at room temperature and does not require any additional ingredients for a successful coating. TYLOPUR ClearCoat Nutra® provides an excellent finish, that can protect tablets from humidity and reduces their overall friability during packaging. Moreover, coating with TYLOPUR ClearCoat Nutra® can improve the mouth feel and swallowability for consumers. Additionally, TYLOPUR ClearCoat Nutra® is recommended for wet granulation to improve particle size, powder flow and compressibility of nutraceutical actives.