METOLOSE

Shin-Etsu Pharma, Nutra and Food Brand

Supplier:Shin-Etsu Pharma, Nutra and Food

Products:23

Shin-Etsu Chemical Co., Ltd. began to produce water soluble cellulose ethers in 1962, with the trade name METOLOSE®. METOLOSE® consists of Methylcellulose (methylcellulose USP) and three substitution types of Hydroxypropylmethylcellulose (Hypromellose USP) each available in several grades differing in viscosity. METOLOSE® can be used as a binder for solid dosage forms such as tablets and granules. It also provides a variety of functions such as water retention, thickening, protective colloid, surface activity, etc. It also can be used as a hydrophilic matrix agent. The hydrophilic matrix system is the simplest sustained release technology for oral dosage forms, consisting essentially of a drug and a water soluble highly viscous polymer. Recent advances in this hydrophilic matrix system have allowed more controllable and reproducible drug release by controlling the chemical and physical properties of the polymer. METOLOSE® SR is especially suitable for this application, and provides a genuine consistency in the final products.

View All METOLOSE Products

METOLOSE® SR 90SH-4000SR

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Sustained Release Agent, Controlled Release Agent, Binder
Dosage Form:Tablets
Labeling Claims:Non-GMO, TSE-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Kosher, Generally Recognized As Safe (GRAS)

METOLOSE® SR 90SH-4000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-100000SR

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Sustained Release Agent, Controlled Release Agent, Binder
Dosage Form:Tablets
Labeling Claims:Non-GMO, TSE-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Kosher, Generally Recognized As Safe (GRAS)

METOLOSE® SR 90SH-100000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-100SR

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Sustained Release Agent, Controlled Release Agent, Binder
Dosage Form:Tablets
Labeling Claims:Non-GMO, TSE-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Kosher, Generally Recognized As Safe (GRAS)

METOLOSE® SR 90SH-100SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-15000SR

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Sustained Release Agent, Controlled Release Agent, Binder
Dosage Form:Tablets
Labeling Claims:Non-GMO, TSE-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Kosher, Generally Recognized As Safe (GRAS)

METOLOSE® SR 90SH-15000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® 65SH-5

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Labeling Claims:Vegan, Non-GMO, Non-Irritant, TSE-free, Allergen-free, Vegetarian, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), EU Compliant

Capsules prepared from hypromellose have advantages in comparison with gelatin based capsules. Hypromellose capsules show a better moisture stability and are suitable for vegetarian/vegan patients. Low viscosity hypromellose products like METOLOSE 65SH-5 is suitable for capsule manufacturing.

METOLOSE® 60SH-50

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Dosage Form:Orally Disintegrating Films (ODFs)
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 60SH-50 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

METOLOSE® 60SH-4000

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Dosage Form:Orally Disintegrating Films (ODFs)
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 60SH-4000 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

METOLOSE® 60SH-10000

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Dosage Form:Orally Disintegrating Films (ODFs)
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 60SH-10000 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

METOLOSE® 65SH-50

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 65SH-50 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

METOLOSE® 65SH-4000

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 65SH-4000 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

METOLOSE® 90SH-4000

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 90SH-4000 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

METOLOSE® 90SH-15000

Chemical Name:Hydroxypropyl Methylcellulose
Functions:Thickener, Viscosity Modifier, Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), FDA Compliant, GMP, JECFA (FAO/WHO), Japan Pharmacopeia (JP), Generally Recognized As Safe (GRAS), REACH (Europe)

METOLOSE® 90SH-15000 is used as a sustained-release agent, thickener, suspending agent and binder for tablets and granules. It is lso used for ophthalmic formulations.

Knowde Brand Summary

Identification

Chemical Name: Hydroxypropyl Methylcellulose,
Methylcellulose
Technologies: Pharmaceuticals & Nutraceuticals
Product Families: Excipients
Binders & Disintegrants,
Formulation & Processing Aids,
Modified & Controlled Release,
Pharmaceutical Coatings
Pharma & Nutraceuticals Functions: Binder,
Coating System,
Controlled Release Agent,
Dispersant,
Sustained Release Agent,
Thickener,
Viscosity Modifier

Features & Benefits

Labeling Claims: Allergen-free,
BSE-free,
Kosher,
Non-GMO,
Non-Hazardous,
Non-Irritant,
Solvent-free,
TSE-free,
Vegan,
Vegetarian

Applications & Uses

Markets: Healthcare & Pharma
Applications: Drug Delivery & Care Solutions
Oral
Pharmaceutical Manufacturing
Excipients & Coatings
Dosage Form: Orally Disintegrating Films (ODFs),
Tablets
Manufacturing Technology: Direct Compression,
Granulation,
Tablet Coating,
Wet Granulation

Knowde Brand Highlights

Brand Highlights: Metolose®

Non ionic and water soluble polymer with various viscosity.

Applicable as film strips and dispersant of liquid formulation

SM-4 is recommendable for pellet coating as it is less sticky. The thermal gelling helps to prevent agglomerations during the coating process even at the higher spray speed.

Metolose® SR

For Hydrophilic matrix formulation of API and METOLOSE® SR to extend the dissolution. The dosage forms can be obtained by direct compression or granulation process.

METOLOSE® SR has specifications of particle size which can be suitable for sustained release application.

Dissolution profile can be easily adjusted by selecting appropriate grade.

Recommendable amount of METOLOSE® SR is more than 20% in the formulation in order to form the stable gel layer.