Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- CAS No.
- 0548-04-09
- Molecular formula
- C30H16O8
- Product Families
- Latin Name
Hypericum perforatum.
- Source of St. John’s wort Extract.
St. John’s wort is name of a Chinese medicine. It is the whole plant of Hypericum perforatum L. Distributed in Hebei, Shaanxi, Gansu, Xinjiang, Shandong, Jiangsu, Jiangxi, Henan, Hubei, Hunan, Sichuan, Guizhou and other places.
- Chemical Structure
Hypericin Molecular Structure
Features & Benefits
- Labeling Claims
- Food Ingredients Features
- St. John’s wort extract Benefits
- Anti-depressant
- Anti-virus, anti-avian flu. (Hypericin is an antiviral pure Chinese medicinal preparation, and it is the first choice for preventing and treating avian influenza.)
- Reduce alcoholism
- Improve seasonal depression
- Premenstrual syndrome (PMS)
Mechanism of action to anti-depression
Hypericum perforatum extract has long been used as an antidepressant in Europe (especially Germany), but research on its mechanism and effective ingredients is still being explored. It is generally believed that Hypericum perforatum, like ordinary antidepressants, inhibits the reabsorption of norepinephrine and serotonin. It is theorized that Hypericum perforatum acts simultaneously in many ways: inhibiting the reabsorption of norepinephrine, serotonin and dopamine; low-level MAOI (monoamine oxidase inhibitor); acting on the hypothalamus, inhibiting cortisol secretion. It is also theorized that the crude extract of Hypericum perforatum has good affinity for some receptors related to the mass transfer of brain nerves, such as GABA (γ-aminobutyric acid). GABA is one of the main substances that calm the central nervous system.
New research shows that GABA is also related to antidepressant. Depression patients have very low GABA levels, and drugs that can enhance GABA activity also have antidepressant effects. It has also been proposed that Hypericum perforatum inhibits the activity of interleukin-6, which is a chemical substance that promotes immunity and can cause depression. And Hypericum perforatum can be used to treat menopausal depression due to the action of β-sitosterol, a mild plant hormone contained. The general view is: Hypericin is the effective antidepressant ingredient of Hypericum perforatum, which works through the MAOI mechanism. However, the researchers doubted that hypericin is the effective ingredient and the MAOI mechanism itself, and proposed new possible effective ingredients: flavonoids (similar to MAOI in chemical structure), such as amantoflavin; mountain ketones ( Inhibit MAO-A, MAO-B) and other unknown ingredients, and it is believed that it may be a synergistic effect of several substances.
Many studies can provide evidence for the effectiveness and safety of Hypericum perforatum against depression. The most convincing is the report of Linde et al. using the statistical method of metoanalysis to deal with random clinical trials. The literature shows that in the treatment of mild and moderate depression, Hypericum perforatum is significantly better than placebo. Compared with standard antidepressants (tricyclics), it has the same effect and less side effects. However, Linde’s experimental treatment course is short and the dose is small. It only studied patients with mild and moderate depression, and did not compare with other standard antidepressants (MAOIs, SSRIs, Effexnor, Paxil, etc.). Therefore, it is believed that Hypericum perforatum can be completely replaced. The conclusion of antidepressants is still immature. At the same time, Hypericum perforatum still has some side effects, including interaction with MAOIs, serotonin syndrome, photosensitivity, gastrointestinal stimulation, fatigue, insomnia and allergic reactions. The LD50 of Hypericum perforatum has not been reported, but the LD50 of some active ingredients is known. For example, the LD50 of hyperin (hyperin) = (0.5±0.014) g/kg. However, 35 times the standard dose of Hypericum perforatum extract was applied to volunteers with only minor side effects. It shows that Hypericum perforatum has higher LD50 and lower toxicity.
- Supplements Containing St. John’s wort Extract
- Now Supplements, Mood Support with St. John’s Wort, Nutrient and Herbal Extracts.
- Nutricost St John’s Wort Capsules.
- Solaray St. Johns Wort Aerial Extract One Daily 900mg.
- Now Supplements, St. John’s Wort (Hypericum perforatum) 300 mg.
- 21st Century St. Johns Wort Extract Veg Capsules.
- Nature’s Truth St. John’s Wort Extract 300 mg.
Applications & Uses
- Markets
- Food & Nutrition Applications
- Dosage for St. John’s wort Extract
Dry herbs (capsules or tablets): The usual dose for the treatment of mild depression and mood disorders is 300 to 500 mg (based on 0.3% Hypericum perforatum extract as the standard), 3 times a day, before meals. Liquid extract (4:1): 40-60 drops twice a day.
Properties
- Appearance
- Dark brown powder
- Odor
- Characteristic
- Taste
- Characteristic
- Specifications
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 504.45 | — | — |
| Hypericins | min 0.3 | % | — |
| Loss on Drying | max. 5 | % | — |
| Ashes | max. 8 | % | — |
| Particle Size (Through 80 mesh) | min. 95 | % | — |
| Heavy Metals | max. 10 | ppm | — |
| Lead Content | max. 2 | ppm | — |
| Arsenic Content | max. 2 | ppm | — |
| Cadmium Content | max. 1.0 | ppm | — |
| Mercury Content | max. 0.1 | ppm | — |
| Total Plate Count | max. 1000 | cfu/g | — |
| Yeast and Mould | max. 100 | cfu/g | — |
| E. coli | max. 0.3 | MPN/g | — |
| Salmonella | Negative | — | — |
| S.aureus | Negative | — | — |
Regulatory & Compliance
Technical Details & Test Data
- Manufacturer Flow Chart of St. John’s wort Extract
Raw Material → Water Extraction → Concentration → Extractum → Spray Drying → Crushing, Mixing, Packaging → Product.
- Specifications
Hypericins UV0.3%-0.7%; Hypericins HPLC0.1%-0.4%.
Safety & Health
- Side Effects of St. John’s wort Extract
Hypericum perforatum extract has become the first choice for the treatment of depression in Europe and America because of its remarkable treatment, low side effects and safe use, and has been included in the pharmacopeias of Germany, the United States and other countries. Volkers et al. found from the controlled clinical treatment of a total of 1,700 depression patients in 26 groups that the equivalent of 0.3% of total hypericin as a therapeutic agent is as effective as modern synthetic antidepressants, and only 3% of patients have relatively harmless This proportion is much lower than modern tricyclic antidepressants.
- Safety of St. John’s wort Extract
St. John’s wort has a good safety record as a folk herb for centuries. Compared with synthetic antidepressants, there are no reports of death caused by taking Hypericum perforatum. Drug follow-up studies on more than 7000 patients and 27 double-blind research trials confirmed its safety. The widespread use of Hypericum perforatum in nearly a million people has not reported serious side effects. Food and Drug Administration (FDA) has not approved the substance for depression or any other medical condition. The FDA, in fact, classifies St. John’s wort as a dietary supplement, not a drug.
Packaging & Availability
- Packaging Type
- St. John’s wort extract Powder Package
- 25kgs/ drum, inner by double plastic bags.
- N.W./G.W.: 25kgs/ 28kgs.
- Drum size: 35cm(diameter)*51cm(height).
- Small order is accepted too. Such like 1kg/ 5kgs/ 10kgs.
Package for small quantity is by aluminum foil bag and carton box.
Storage & Handling
- Notes for Shipping
- For 1-50kg, we suggest shipping by courier, such as DHL, fedex. HS code we use is 2932999099.
- For 50-300kgs, we suggest shipping by air. HS code we use is 2932999099/1302199099.
- For more than 300kgs, we suggest shipping by sea. HS code we use is 1302199099.