Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Animal Feed & Nutrition Functions
- Ingredients
- Egg Membrane, Hydrolyzed
- Technologies
Features & Benefits
- Labeling Claims
- Animal Feed & Nutrition Features
Applications & Uses
- Markets
- Feeding Instructions
DOGS - CATS
NEM®-CA should be formulated into dogs and cats’ diets to meet 13.5 mg/kg body weight/day, and should also be optimized for breed, size and life stage of the animal.
The recommended daily dose of NEM®-CA in pet supplements and treats:
• Dogs small/toy (5 to 11 Kg): 150 mg/day
• Dogs medium (11 to 25 Kg): 300 mg/day
• Dogs large (25 to 35 Kg): 450 mg/day
• Dogs giant (35 to 45 Kg): 600 mg/day
• Cats (5 to 11 Kg): 150 mg/dayHORSES
Horses: recommended daily dose 1,500 to 3,000 mg/day
Properties
- Appearance
- Off-white powder
- Typical Properties
- Microbiological Values
- Nutritional Information
- Specifications
- Heavy Metals
- Nutrient Values
Composition: partially hydrolyzed eggshell membrane.
Naturally occurring nutrients:
• Proteins: Min. 45%
• Hyaluronic acid: Min. 0.3%
• Total sulfated glycosaminoglycans (sGAG): Min. 0.1%
• Collagen: Min. 3%
• Calcium: 13 to 15% (typical value)
| Value | Units | Test Method / Conditions | |
| Bulk Density (loose) | min. 0.5 | g/cc | ESM-TM-PH003 |
| Bulk Density (tapped) | min. 0.6 | g/cc | ESM-TM-PH003 |
| Moisture Content | max.7 | % | ESM-TM-CHO05 or ESM-TM-NROO1 |
| Particle Size (retained on #60mesh (250 Micron)) | max. 5 | % | ESM-TM-PHOO2 |
| Total Sulfated Glycosaminoglycons as Chondroitin Sulfate | min. 0.1 | % | ESM-TM-UV006 |
| Water Activity | max. 0.31 | a w | ESM-TM-CH010 |
| Value | Units | Test Method / Conditions | |
| Enterobacteriaceae | max. 20 | cfu/g | ESM-TM-MB005 or ESM-TM-MB006 |
| Escherichia coli | Negative | /25g | USP <2022> or ESM-TM-MBO006 |
| Pseudomones aeruginosa | Negative | /25g | USP <61> or ESM-TM-MB006 |
| Salmonella | Negative | /375g | AOAC RI100201 (PCR) |
| Staphylococcus aureus | Negative | /25g | USP <2022> or ESM-TM-MBO006 |
| Total Plate Count | max. 5,000 | cfu/g | USP <2021> or ESM-TM-MBO06 |
| Yeast and Mold Count | max. 300 | cfu/g | USP <2021> or ESM-TM-MBO06 |
| Value | Units | Test Method / Conditions | |
| Calcium Content | 12 -18 | % | ESM-TM-CH001 or ESM-TM-NR001 |
| Total Protein | min.48 | % | AOAC 984.13 or ESM-TM-NROO1 |
| Value | Units | Test Method / Conditions | |
| Collagen | min. 3 | % | ESM-TM-UV003 |
| Hyaluronic Acid | min. 0.3 | % | ESM-TM-UV001 |
| Value | Units | Test Method / Conditions | |
| Arsenic Content | max. 1.5 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
| Cadmium Content | max. 0.5 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
| Lead Content | max. 0.5 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
| Mercury Content | max. 0.2 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Effect of NEM® on Quality of Life (QOL)
The number of owners reporting the QOL of their dogs as “Very Good” and “Excellent” increased by 41% in NEM-treated group.
- Effect of NEM® on Pain, Function & Quality of Life
- NEM® 3X Joint Defence
Pain Reduction*
Even minor day-to-day injuries can cause pain and discomfort in and around our joints. Two healthy person studies demonstrate that NEM® may help provide a rapid reduction of exercise-induced joint aches and pains. The first study, published in 2017, was a randomized, double-blind, placebo-controlled trial (RCT) in healthy post-menopausal women; and revealed NEM’s ability to reduce joint pain associated with exercise in just 8 days.* The positive results were confirmed in a second healthy person trial that included both sexes and a wider age range of subjects. (In pre-publication). None of the subjects in either trial had pre-existing joint complaints. NEM® is the first dietary ingredient that has been shown to reduce exercise- induced pain in truly healthy subjects. It has also demonstrated significant reduction in pain in 7-10 days in 7 other published clinical trials.*
Stiffness Reduction*
Healing requires a healthy inflammatory response to everyday wear and tear. NEM® research has demonstrated a significant reduction in stiffness in four open label studies* and three double-blind placebo-controlled trials.* In a healthy person clinical trial, a significant reduction in exercise-induced stiffness was demonstrated in a quick 4 days.*
Cartilage Protection*
NEM® takes joint support to a higher level by helping protect joint cartilage. Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear.*In vivo, veterinary and human clinical studies demonstrate
the action of NEM® in reducing levels of CTX-II, a recognized biomarker of Type II collagen degradation (the predominant collagen type found in cartilage tissue).* In the 2017 RCT study, a substantial chondroprotective effect was demonstrated from NEM® supplementation through a lasting decrease in CTX-II.*
Joint space width (white space) is substantially reduced in the arthritic control knee.
Animal studies demonstrate the positive effects of NEM on joint tissue in collageninduced arthritic rats.
Cartilage (dark purple) is substantially thicker in the NEM-treated knee.
Furthermore, prior in vivo and in vitro studies show that NEM® may promote a healthy inflammatory response.*These studies consistently reveal NEM’s selective action in reducing a broad range of pro-inflammatory substances often associated with joint inflammation, such as TNF-α, and both serum and synovial IL-1β.(5-8) Additional published research has revealed that NEM supplementation can decrease levels of the inflammatory marker, CRP(7), and influence the gene transcription factor NF-kB.*(10) NF-kB plays a fundamental role in the function of the immune system and its action occurs very early in the inflammatory cascade.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Beneficial effects of NEM® vs placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women.12
Packaging & Availability
- Packaging Type
- Packaging
Packaging : 15 Kg poly-lined boxes
Pallet : 27 Carton Boxes (405 Kg)- Packaging
Warehouse Location : Carthage, Missouri
Storage & Handling
- Shelf Life
3 Years when stored as directed
- Storage
Optimal storage conditions are 18-30°C in dry, sealed container.
- SAMPLING & STORAGE
Recommended Retest Interval <36 MO. Reserve Sample Quantity 400 - 500 g Bulk & Sample Storage Condition 18-30 °C Reserve Sample Container min. 16 OZ. POLY BAG