NEM® CA for companion animals is a partially hydrolyzed eggshell membrane that contains a unique blend of essential nutrients to support joint health, flexibility as well as cartilage protection. This single matrix includes glycosaminoglycans like hyaluronic acid, chondroitin, and glucosamine, as well as collagen and amino acids rich in sulfur.

Ingredient Name: Eggshell Membrane, Hydrolyzed

Animal Species: Cats, Dogs, Horses, Pets

Functions: Supplement

Labeling Claims: BSE-free, Kosher, Non-GMO, TSE-free, Vegetarian

Certifications & Compliance: GMP, Kosher, NSF Approved

Features: Joint Support

Knowde Enhanced TDS

Identification & Functionality

Animal Feed & Nutrition Functions
Egg Membrane, Hydrolyzed

Features & Benefits

Animal Feed & Nutrition Features

Applications & Uses

Animal Species
Feeding Instructions


NEM®-CA should be formulated into dogs and cats’ diets to meet 13.5 mg/kg body weight/day, and should also be optimized for breed, size and life stage of the animal.

The recommended daily dose of NEM®-CA in pet supplements and treats:

• Dogs small/toy (5 to 11 Kg): 150 mg/day
• Dogs medium (11 to 25 Kg): 300 mg/day
• Dogs large (25 to 35 Kg): 450 mg/day
• Dogs giant (35 to 45 Kg): 600 mg/day
• Cats (5 to 11 Kg): 150 mg/day



Horses: recommended daily dose 1,500 to 3,000 mg/day


Physical Form
Off-white powder
Typical Properties
ValueUnitsTest Method / Conditions
Bulk Density (loose)min. 0.5g/ccESM-TM-PH003
Bulk Density (tapped)min. 0.6g/ccESM-TM-PH003
Moisture Contentmax.7%ESM-TM-CHO05 or ESM-TM-NROO1
Particle Size (retained on #60mesh (250 Micron))max. 5%ESM-TM-PHOO2
Total Sulfated Glycosaminoglycons as Chondroitin Sulfatemin. 0.1% ESM-TM-UV006
Water Activitymax. 0.31a wESM-TM-CH010
Microbiological Values
ValueUnitsTest Method / Conditions
Enterobacteriaceaemax. 20cfu/gESM-TM-MB005 or ESM-TM-MB006
Escherichia coliNegative/25gUSP <2022> or ESM-TM-MBO006
Pseudomones aeruginosaNegative/25gUSP <61> or ESM-TM-MB006
SalmonellaNegative/375gAOAC RI100201 (PCR)
Staphylococcus aureusNegative/25gUSP <2022> or ESM-TM-MBO006
Total Plate Countmax. 5,000cfu/gUSP <2021> or ESM-TM-MBO06
Yeast and Mold Countmax. 300cfu/gUSP <2021> or ESM-TM-MBO06
Nutritional Information
ValueUnitsTest Method / Conditions
Calcium Content12 -18%ESM-TM-CH001 or ESM-TM-NR001
Total Proteinmin.48%AOAC 984.13 or ESM-TM-NROO1
ValueUnitsTest Method / Conditions
Collagenmin. 3%ESM-TM-UV003
Hyaluronic Acidmin. 0.3% ESM-TM-UV001
Heavy Metals
ValueUnitsTest Method / Conditions
Arsenic Contentmax. 1.5ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Cadmium Contentmax. 0.5ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Lead Contentmax. 0.5ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Mercury Contentmax. 0.2ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Nutrient Values

Composition: partially hydrolyzed eggshell membrane.
Naturally occurring nutrients:
• Proteins: Min. 45%
• Hyaluronic acid: Min. 0.3%
• Total sulfated glycosaminoglycans (sGAG): Min. 0.1%
• Collagen: Min. 3%
• Calcium: 13 to 15% (typical value)

Regulatory & Compliance

Certifications & Compliance

Technical Details & Test Data

Effect of NEM® on Quality of Life (QOL)

NEM® CA - Effect of Nem® On Quality of Life (Qol)

The number of owners reporting the QOL of their dogs as “Very Good” and “Excellent” increased by 41% in NEM-treated group.

Effect of NEM® on Pain, Function & Quality of Life

NEM® CA - Effect of Nem® On Pain, Function & Quality of Life

NEM® 3X Joint Defence

Pain Reduction*

Even minor day-to-day injuries can cause pain and discomfort in and around our joints. Two healthy person studies demonstrate that NEM® may help provide a rapid reduction of exercise-induced joint aches and pains. The first study, published in 2017, was a randomized, double-blind, placebo-controlled trial (RCT) in healthy post-menopausal women; and revealed NEM’s ability to reduce joint pain associated with exercise in just 8 days.* The positive results were confirmed in a second healthy person trial that included both sexes and a wider age range of subjects. (In pre-publication). None of the subjects in either trial had pre-existing joint complaints. NEM® is the first dietary ingredient that has been shown to reduce exercise- induced pain in truly healthy subjects. It has also demonstrated significant reduction in pain in 7-10 days in 7 other published clinical trials.*


Stiffness Reduction*

Healing requires a healthy inflammatory response to everyday wear and tear. NEM® research has demonstrated a significant reduction in stiffness in four open label studies* and three double-blind placebo-controlled trials.* In a healthy person clinical trial, a significant reduction in exercise-induced stiffness was demonstrated in a quick 4 days.*


Cartilage Protection*

NEM® takes joint support to a higher level by helping protect joint cartilage. Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear.*In vivo, veterinary and human clinical studies demonstrate
the action of NEM® in reducing levels of CTX-II, a recognized biomarker of Type II collagen degradation (the predominant collagen type found in cartilage tissue).* In the 2017 RCT study, a substantial chondroprotective effect was demonstrated from NEM® supplementation through a lasting decrease in CTX-II.*


NEM® CA - Nem® 3X Joint Defence

Joint space width (white space) is substantially reduced in the arthritic control knee.

Animal studies demonstrate the positive effects of NEM on joint tissue in collageninduced arthritic rats.

NEM® CA - Nem® 3X Joint Defence - 1

Cartilage (dark purple) is substantially thicker in the NEM-treated knee.

Furthermore, prior in vivo and in vitro studies show that NEM® may promote a healthy inflammatory response.*These studies consistently reveal NEM’s selective action in reducing a broad range of pro-inflammatory substances often associated with joint inflammation, such as TNF-α, and both serum and synovial IL-1β.(5-8) Additional published research has revealed that NEM supplementation can decrease levels of the inflammatory marker, CRP(7), and influence the gene transcription factor NF-kB.*(10) NF-kB plays a fundamental role in the function of the immune system and its action occurs very early in the inflammatory cascade.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Beneficial effects of NEM® vs placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women.12

NEM® CA - Nem® 3X Joint Defence - 2

Packaging & Availability

Packaging Type

Packaging : 15 Kg poly-lined boxes
Pallet : 27 Carton Boxes (405 Kg)


Warehouse Location : Carthage, Missouri

Storage & Handling

Shelf Life

3 Years when stored as directed


Optimal storage conditions are 18-30°C in dry, sealed container.

Recommended Retest Interval <36 MO.
Reserve Sample Quantity 400 - 500 g
Bulk & Sample Storage Condition 18-30 °C
Reserve Sample Container min. 16 OZ. POLY BAG