NEM® Standard

Pain Reduction*

Even minor day-to-day injuries can cause pain and discomfort in and around our joints. Two healthy person studies demonstrate that NEM® may help provide a rapid reduction of exercise-induced joint aches and pains. The first study, published in 2017, was a randomized, double-blind, placebo-controlled trial (RCT) in healthy post-menopausal women; and revealed NEM’s ability to reduce joint pain associated with exercise in just 8 days.* The positive results were confirmed in a second healthy person trial that included both sexes and a wider age range of subjects. (In pre-publication). None of the subjects in either trial had pre-existing joint complaints. NEM® is the first dietary ingredient that has been shown to reduce exercise- induced pain in truly healthy subjects. It has also demonstrated significant reduction in pain in 7-10 days in 7 other published clinical trials.*

Stiffness Reduction*

Healing requires a healthy inflammatory response to everyday wear and tear. NEM® research has demonstrated a significant reduction in stiffness in four open label studies* and three double-blind placebo-controlled trials.* In a healthy person clinical trial, a significant reduction in exercise-induced stiffness was demonstrated in a quick 4 days.*

Cartilage Protection*

NEM® takes joint support to a higher level by helping protect joint cartilage. Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear.*In vivo, veterinary and human clinical studies demonstrate
the action of NEM® in reducing levels of CTX-II, a recognized biomarker of Type II collagen degradation (the predominant collagen type found in cartilage tissue).* In the 2017 RCT study, a substantial chondroprotective effect was demonstrated from NEM® supplementation through a lasting decrease in CTX-II.*

Joint space width (white space) is substantially reduced in the arthritic control knee.

Animal studies demonstrate the positive effects of NEM on joint tissue in collageninduced arthritic rats.

Cartilage (dark purple) is substantially thicker in the NEM-treated knee.

Furthermore, prior in vivo and in vitro studies show that NEM® may promote a healthy inflammatory response.*These studies consistently reveal NEM’s selective action in reducing a broad range of pro-inflammatory substances often associated with joint inflammation, such as TNF-α, and both serum and synovial IL-1β.(5-8) Additional published research has revealed that NEM supplementation can decrease levels of the inflammatory marker, CRP(7), and influence the gene transcription factor NF-kB.*(10) NF-kB plays a fundamental role in the function of the immune system and its action occurs very early in the inflammatory cascade.

Beneficial effects of NEM® vs placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women.12

The number of owners reporting the QOL of their dogs as “Very Good” and “Excellent” increased by 41% in NEM-treated group.