Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Ingredient Origin
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Ingredients
- Egg Membrane, Hydrolyzed
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Key Features
The #1 fast-acting, triple-action, branded eggshell membrane ingredient on the market.
NEM® is a natural, food-sourced, complete joint health ingredient in a small 500mg daily dose that provides greater formulation fl exibility. Research reveals that NEM supplementation can help reduce exercise-induced joint pain, stiffness, and help protect cartilage against breakdown.* No other joint health ingredient on the market can claim this triple-action effect and is backed with a vast published research portfolio.
Applications & Uses
- Markets
- Applications
- Food & Nutrition Applications
Properties
- Appearance
- Off-white powder
- Physical Properties
- Typical Properties
- Microbiological Values
- Nutritional Information
- Specifications
- Heavy Metals
| Value | Units | Test Method / Conditions | |
| Bulk Density (loose) | min. 0.5 | g/cc | ESM-TM-PH003 |
| Bulk Density (tapped) | min. 0.7 | g/cc | ESM-TM-PHO03 |
| Particle Size (retained on #60mesh (250 Micron)) | max. 5 | % | ESM-TM-PHO02 |
| Value | Units | Test Method / Conditions | |
| Moisture Content | max. 7 | % | ESM-TM-CHO05 or ESM-TM-NROO1 |
| Total Sulfated Glycosaminoglycans as Chondroitin Sulfate | min. 0.2 | % | ESM-TM-UV006 |
| Water Activity | max. 0.6 | a w | ESM-TM-CH010 |
| Value | Units | Test Method / Conditions | |
| Enterobacteriaceae | max. 20 | cfu/g | ESM-TM-MB005 or ESM-TM-MB006 |
| Escherichia coli | Negative | /25g | USP <2022> or ESM-TM-MB006 |
| Pseudomones aeruginosa | Negative | /25g | USP <61> or ESM-TM-MBO006 |
| Salmonella | Negative | /375g | AOAC RI100201 (PCR) |
| Staphylococcus aureus | Negative | /25g | USP <2022> or ESM-TM-MBO06 |
| Total Plate Count | max. 5,000 | cfu/g | USP <2021> or ESM-TM-MB006 |
| Yeast and Mold Count | max. 300 | cfu/g | USP <2021> or ESM-TM-MB006 |
| Value | Units | Test Method / Conditions | |
| Calcium Content | 12 -18 | % | ESM-TM-CHO01 or ESM-TM-NROO1 |
| Total Protein | min. 46 | % | AOAC 984.13 or ESM-TM-NROO1 |
| Value | Units | Test Method / Conditions | |
| Collagen | min. 3 | % | ESM-TM-UV003 |
| Conform | NA | — | ESM-TM-IR801 or ESM-TM-NROO1 |
| Hyaluronic Acid | min. 0.5 | % | ESM-TM-UV001 |
| Value | Units | Test Method / Conditions | |
| Arsenic Content | max. 0.25 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
| Cadmium Content | max. 10 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
| Lead Content | max. 10 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
| Mercury Content | max. 10 | ppm | AOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes) |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- NEM® 3X Joint Defence
Pain Reduction*
Even minor day-to-day injuries can cause pain and discomfort in and around our joints. Two healthy person studies demonstrate that NEM® may help provide a rapid reduction of exercise-induced joint aches and pains. The first study, published in 2017, was a randomized, double-blind, placebo-controlled trial (RCT) in healthy post-menopausal women; and revealed NEM’s ability to reduce joint pain associated with exercise in just 8 days.* The positive results were confirmed in a second healthy person trial that included both sexes and a wider age range of subjects. (In pre-publication). None of the subjects in either trial had pre-existing joint complaints. NEM® is the first dietary ingredient that has been shown to reduce exercise- induced pain in truly healthy subjects. It has also demonstrated significant reduction in pain in 7-10 days in 7 other published clinical trials.*
Stiffness Reduction*
Healing requires a healthy inflammatory response to everyday wear and tear. NEM® research has demonstrated a significant reduction in stiffness in four open label studies* and three double-blind placebo-controlled trials.* In a healthy person clinical trial, a significant reduction in exercise-induced stiffness was demonstrated in a quick 4 days.*
Cartilage Protection*
NEM® takes joint support to a higher level by helping protect joint cartilage. Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear.*In vivo, veterinary and human clinical studies demonstrate
the action of NEM® in reducing levels of CTX-II, a recognized biomarker of Type II collagen degradation (the predominant collagen type found in cartilage tissue).* In the 2017 RCT study, a substantial chondroprotective effect was demonstrated from NEM® supplementation through a lasting decrease in CTX-II.*
Joint space width (white space) is substantially reduced in the arthritic control knee.
Animal studies demonstrate the positive effects of NEM on joint tissue in collageninduced arthritic rats.
Cartilage (dark purple) is substantially thicker in the NEM-treated knee.
Furthermore, prior in vivo and in vitro studies show that NEM® may promote a healthy inflammatory response.*These studies consistently reveal NEM’s selective action in reducing a broad range of pro-inflammatory substances often associated with joint inflammation, such as TNF-α, and both serum and synovial IL-1β.(5-8) Additional published research has revealed that NEM supplementation can decrease levels of the inflammatory marker, CRP(7), and influence the gene transcription factor NF-kB.*(10) NF-kB plays a fundamental role in the function of the immune system and its action occurs very early in the inflammatory cascade.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Beneficial effects of NEM® vs placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women.12
- Effect of NEM® on Quality of Life (QOL)
The number of owners reporting the QOL of their dogs as “Very Good” and “Excellent” increased by 41% in NEM-treated group.
- Effect of NEM® on Pain, Function & Quality of Life
Packaging & Availability
- Packaging
Bulk Packaging : 15 Kg Poly-Lined Boxes
Storage & Handling
- SAMPLING & STORAGE
Recommended Retest Interval <36 MO. Reserve Sample Quantity 400 - 500 g Bulk & Sample Storage Condition 18-30 °C Reserve Sample Container min. 16 OZ. POLY BAG