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NEM® Standard

NEM® Standard is a branded eggshell membrane containing three times the joint health support in one powerful ingredient. It has been shown to help support healthy joints against pain, stiffness, and cartilage breakdown in as little as 4–11 days. Moreover, it is sustainably sourced from a renewable supply of US-domestic eggshells.

Brand: NEM (2 products)

Ingredient Name: Eggshell Membrane, Hydrolyzed

Ingredient Origin: Natural Origin

Labeling Claims: BSE-free, GMO-free, Halal, Kosher, Natural, Naturally Derived, Non-GMO, Other Labeling Claims, TSE-free, Vegetarian

Certifications & Compliance: GMP, Generally Recognized As Safe (GRAS), Halal, Kosher, NSF Approved

Benefit Claims (Health): Pain Reduction

Features: Anti-Inflammatory, Healthy Ageing, Protein Enrichment, Supports Healthy Joints

Enhanced TDS

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Ingredient Origin
Food Ingredients Functions
Pharma & Nutraceuticals Functions
Egg Membrane, Hydrolyzed

Features & Benefits

Benefit Claims (Health)
Key Features

The #1 fast-acting, triple-action, branded eggshell membrane ingredient on the market.

NEM® is a natural, food-sourced, complete joint health ingredient in a small 500mg daily dose that provides greater formulation fl exibility. Research reveals that NEM supplementation can help reduce exercise-induced joint pain, stiffness, and help protect cartilage against breakdown.* No other joint health ingredient on the market can claim this triple-action effect and is backed with a vast published research portfolio.

Applications & Uses


Physical Form
Off-white powder
Physical Properties
ValueUnitsTest Method / Conditions
Bulk Density (loose)min. 0.5g/ccESM-TM-PH003
Bulk Density (tapped)min. 0.7g/ccESM-TM-PHO03
Particle Size (retained on #60mesh (250 Micron))max. 5%ESM-TM-PHO02
Typical Properties
ValueUnitsTest Method / Conditions
Moisture Contentmax. 7%ESM-TM-CHO05 or ESM-TM-NROO1
Total Sulfated Glycosaminoglycans as Chondroitin Sulfatemin. 0.2% ESM-TM-UV006
Water Activitymax. 0.6a wESM-TM-CH010
Microbiological Values
ValueUnitsTest Method / Conditions
Enterobacteriaceaemax. 20cfu/gESM-TM-MB005 or ESM-TM-MB006
Escherichia coliNegative/25gUSP <2022> or ESM-TM-MB006
Pseudomones aeruginosaNegative/25gUSP <61> or ESM-TM-MBO006
SalmonellaNegative/375gAOAC RI100201 (PCR)
Staphylococcus aureusNegative/25gUSP <2022> or ESM-TM-MBO06
Total Plate Countmax. 5,000cfu/gUSP <2021> or ESM-TM-MB006
Yeast and Mold Countmax. 300cfu/gUSP <2021> or ESM-TM-MB006
Nutritional Information
ValueUnitsTest Method / Conditions
Calcium Content12 -18%ESM-TM-CHO01 or ESM-TM-NROO1
Total Proteinmin. 46%AOAC 984.13 or ESM-TM-NROO1
ValueUnitsTest Method / Conditions
Collagenmin. 3%ESM-TM-UV003
ConformNA-ESM-TM-IR801 or ESM-TM-NROO1
Hyaluronic Acidmin. 0.5% ESM-TM-UV001
Heavy Metals
ValueUnitsTest Method / Conditions
Arsenic Contentmax. 0.25ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Cadmium Contentmax. 10ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Lead Contentmax. 10ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)
Mercury Contentmax. 10ppmAOAC 993.14 (icp-ms) or ESM-TM-CHO13 (icp-aes)

Regulatory & Compliance

Technical Details & Test Data

NEM® 3X Joint Defence

Pain Reduction*

Even minor day-to-day injuries can cause pain and discomfort in and around our joints. Two healthy person studies demonstrate that NEM® may help provide a rapid reduction of exercise-induced joint aches and pains. The first study, published in 2017, was a randomized, double-blind, placebo-controlled trial (RCT) in healthy post-menopausal women; and revealed NEM’s ability to reduce joint pain associated with exercise in just 8 days.* The positive results were confirmed in a second healthy person trial that included both sexes and a wider age range of subjects. (In pre-publication). None of the subjects in either trial had pre-existing joint complaints. NEM® is the first dietary ingredient that has been shown to reduce exercise- induced pain in truly healthy subjects. It has also demonstrated significant reduction in pain in 7-10 days in 7 other published clinical trials.*


Stiffness Reduction*

Healing requires a healthy inflammatory response to everyday wear and tear. NEM® research has demonstrated a significant reduction in stiffness in four open label studies* and three double-blind placebo-controlled trials.* In a healthy person clinical trial, a significant reduction in exercise-induced stiffness was demonstrated in a quick 4 days.*


Cartilage Protection*

NEM® takes joint support to a higher level by helping protect joint cartilage. Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear.*In vivo, veterinary and human clinical studies demonstrate
the action of NEM® in reducing levels of CTX-II, a recognized biomarker of Type II collagen degradation (the predominant collagen type found in cartilage tissue).* In the 2017 RCT study, a substantial chondroprotective effect was demonstrated from NEM® supplementation through a lasting decrease in CTX-II.*


NEM® Standard - Nem® 3X Joint Defence

Joint space width (white space) is substantially reduced in the arthritic control knee.

Animal studies demonstrate the positive effects of NEM on joint tissue in collageninduced arthritic rats.

NEM® Standard - Nem® 3X Joint Defence  - 1

Cartilage (dark purple) is substantially thicker in the NEM-treated knee.

Furthermore, prior in vivo and in vitro studies show that NEM® may promote a healthy inflammatory response.*These studies consistently reveal NEM’s selective action in reducing a broad range of pro-inflammatory substances often associated with joint inflammation, such as TNF-α, and both serum and synovial IL-1β.(5-8) Additional published research has revealed that NEM supplementation can decrease levels of the inflammatory marker, CRP(7), and influence the gene transcription factor NF-kB.*(10) NF-kB plays a fundamental role in the function of the immune system and its action occurs very early in the inflammatory cascade.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Beneficial effects of NEM® vs placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women.12

NEM® Standard - Nem® 3X Joint Defence  - 2

Effect of NEM® on Quality of Life (QOL)

NEM® Standard - Effect of Nem® On Quality of Life (Qol)

The number of owners reporting the QOL of their dogs as “Very Good” and “Excellent” increased by 41% in NEM-treated group.

Effect of NEM® on Pain, Function & Quality of Life

NEM® Standard - Effect of Nem® On Pain, Function & Quality of Life

Packaging & Availability

Packaging Type

Bulk Packaging : 15 Kg Poly-Lined Boxes

Storage & Handling

Recommended Retest Interval <36 MO.
Reserve Sample Quantity 400 - 500 g
Bulk & Sample Storage Condition 18-30 °C
Reserve Sample Container min. 16 OZ. POLY BAG