Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Highlights
- Type III collagen is a structural protein that makes up the extracellular matrix (ECM) and provides space for cell growth with a supportive function.
- Type III collagen plays an important role for skin elasticity and moisturizing, and also works significantly for scar healing and anti-aging.
- Trautec ReCol3 was selected by highly bioactive fragments from the amino acid sequence of natural human Type IIl collagen, and using genetic engineering techniques with eukaryotic yeast to construct an expression system by using biofermentation technology.
- Product Features
- 100% homologous with human collagen, highly biocompatibility
- Multi-stage purification
- Lyophilization preparation
- Higher purity
- Safer expression in eukaryotic yeast
- Extra-long sequences
- Higher activity
Applications & Uses
- Markets
- Skin Care Applications
- Sun Care Applications
- Treatment Product Applications
- Use Level
- 0.01 - 5%
Properties
- Appearance
- White to off white liquid
- Odor
- No or slightly characteristic odor
- Microbiological Values
- Specifications
- Test Methods
- Appearance: Determined according to the standard operating procedures for sensory index inspection (Document No.: qc-sop-03-009).
- Collagen content: Determine the collagen content according to the standard operating procedures for the inspection of recombinant collagen content (Kjeldahl method) (Document No.: qc-sop-03-011), and the nitrogen conversion coefficient is 5.039.
- pH: Prepare 1.0% aqueous solution and determine it according to the determination method of standard operating procedures for pH value inspection (Document No.: qc-sop-0 3-005).
- Loss on drying: According to the standard operating procedures for loss on drying inspection (Document No.: qc-sop-03-003).
- Ignition residue: Determined according to the standard operating procedures for the inspection of ignition residue (Document No.: qc-sop-03-004).
- Microbial limit: Test according to the standard operating procedures for microbial limit. (Safety technical specification for cosmetics) (Document No.: qc-sop-03-008). Heavy metals contact a third-party organization and refer to the physical and chemical test methods in Chapter 4 of the 2015 technical code for the safety of cosmetics: 1.2 mercury, 1.3 lead, 1.4 arsenic, and 1.5 cadmium.
- Methanol: contact a third-party organization and refer to Chapter 4 physical and chemical test methods in 2015 edition of technical specifications for safety of cosmetics: 2.2 2 method in methanol for test.
- Identification 2 (Infrared Spectrum)
- The infrared spectrum shall be consistent with that of the reference substance.
- Test Method : It shall be tested by infrared spectrophotometry according to the general rule 0402 of Part IV of Pharmacopeia of the PPC, 2020 edition. Among them, amide A-band and B-band appear at the wave number of about 3500 ~ 3000cm−1. Amide I band appeared at about 1680-1630cm−1. Amide II band appeared at about 1300-1200cm−1. Amide III band appeared at about 1640-1500cm−1.
| Value | Units | Test Method / Conditions | |
| Total Number of Colonies | max. 1000 | CFU/g | — |
| Total Number of Molds and Yeasts | max. 100 | CFU/g | — |
| Staphylococcus Aureus | None | — | — |
| Pseudomonas Aeruginosa | None | — | — |
| Heat Resistant Coliform | None | — | — |
| Value | Units | Test Method / Conditions | |
| Collagen Content | min. 1.0 | % | — |
| pH | 3.5 - 7.0 | — | — |
| Lead Content | max. 10 | mg/Kg | — |
| Mercury Content | max. 1 | mg/Kg | — |
| Arsenic Content | max. 2 | mg/Kg | — |
| Cadmium Content | max. 5.0 | mg/Kg | — |
| Methanol Content | max. 2000 | mg/Kg | — |
| Loss on Drying | max. 5.0 | % | — |
| Incendiary Residue | max. 2.0 | % | — |
| Molecular Weight | 43.6 | kDa | — |
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Test Data
Clinical Trials
Volunteers applied 0.2% SRHC Type ll cream to the entire face every morning and evening for 28 days.
In Vitro Efficacy
1. Restoration Capacity Assessment, Cell scratch test (HACAT)
Result : Trautec ReCol3 significantly promoted cell migration and had tissue damage repair function.
2. Anti-Wrinkle Effect - In vitro ex vivo skin model Masson staining experiments
Result : Trautec ReCol3 had a significant elevating effect on collagen fiber content for UV-induced UV damage with 0.2% Trautec ReCol3.
3. Soothing Inflammation
a. EpiKutis epidermal model Detection of PGE2
## denotes comparison with BC, p<0.01
** denotes comparison with NC, P<0.01Result : 0.2% Trautec ReCol3 had a significant inhibitory effect on PGE2 induced by SLS stimulation and reduced PGE2 secretion level.
b. EpiKutis epidermal model TRPV1 test
Result : 0.2% Trautec ReCol3 significantly down-regulated TRPV1 protein expression induced by SLS stimulation
Packaging & Availability
- Packaging Type
- Packaging Information
- Packaging: 1kg/bag, 5kg/bag or according to the order requirements.
- Inner: PE bag; Outer: aluminum bag
Storage & Handling
- Shelf Life
- 2 Years
- Storage Information
Keep container closed at room temperature.