Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- Molecular Formula
- C80H126O44
- CAS No.
- 15588-68-8
- Ingredients
- Gynostemma Pentaphyllum Extract
- Technologies
- Chemical components of Gynostemma
- The main bioactive ingredients of Jiaogulan are saponins, flavonoids, chlorophyll, and carotenoids. Among them, saponins and flavonoids are identified as the beneficial features of gynostemma.
- More than 230 compounds have been identified as being derived from G. pentaphyllum, and it can be divided into saponins, sterols, flavonoids, polysaccharides, and several other compounds according to its chemical structure.
- Over 165 dammarane triterpene saponins, ( known as gypenosides), have been identified from Jiaogulan and four (gypenoside III, IV, VIII and XII) of them are identical to the Panax ginseng (ginsenoside Rb1, Rb3, Rd and F2, respectively) , what’s more, the amounts of these ingredients in GpM is more abundant than the Panax ginseng ‘s. Flavonoids are the most often polyphenolic plant compounds, which is also referred to vitamin P, Flavonoids extracted from G. pentaphyllum mainly composed of kaempferol and quercetin derivatives.
- Botanic Name
Gynostemma pentaphyllum (Thunb.) Makino
- Active Ingredients
Gypenosides
Features & Benefits
- Food Ingredients Features
- Features
Weight Loss
- The science behind gynostemma extract for weight loss? Because of AMPK Activation and Promoting Fat Metabolism.
- Gynostemma extract helps lower triglycerides and bad cholesterol in the blood through strengthening the liver’s ability to improve lipid metabolism.
- Gynostemma extract promotes the liver to convert the carbohydrates into energy instead of triglycerides. Triglycerides are stored as fatty deposits in the body. AMPK is an enzyme that acts as a significant metabolic switch. It decides whether the energy should be used to meet immediate energy requirements at hand or stored as fat for future use. Gynostemma extract is beneficial to AMPK activation. The enzyme signals the body to start consuming the energy rather than storing it as fat.
- Besides, Gynostemma extract can inhibit cholesterol absorption by the body. Our body needs cholesterol to make bile acids, which are released into our intestines to digest food. Jiaogulan extract can bind the bile and cholesterol molecules to prevent their reabsorption by the body. These adhering fat molecules are excreted from the body.
Anti-tumor
- Gynostemma extract has a significant anti-tumor effect in vitro and in vivo. Its mechanism of action is to inhibit the growth and reproduction of cancer cells through direct cytotoxicity. Some studies have shown that gynostemma extract has significant inhibitory effects on cultured melanoma cells (B16), Leukemia cell (L1210), lung cancer cells (3LL) and liver cancer cells (MH1C1). The inhibition effect was correlated to the concentration of GpM in the range of 2-10 ug/mL. Also, there was no adverse effect on the proliferation of normal cells.
- Besides, the total saponins of gynostemma extract have direct effects on killing cultured mouse ascites cancer (EAC) and cervical cancer cells (HeLa S3). The extracts also have visible lethal effects on human gastric cancer, cervical cancer, tongue cancer, and other cultured cancer cells.
Heart healer & Improved Circulation
- Animal experiments show that gypenoside have extensive protective effects on the cardiovascular and cerebrovascular system. It has a protective effect on myocardial ischemia and systolic cardiac function. It can improve the cardiotonic impact and play a critical role in central inhibitory by inhibiting the activities of Na+, K+-ATPase in the heart and brain.
- It can protect against heart damage from oxygen free radicals, benefit to the integrity of myocardial cell membrane and improve the diastolic function of the myocardium during acute myocardial ischemia.
Diabetes
- Diabetes mellitus has become the third largest chronic disease in the world. In recent years, many studies have found that gynostemma pentaphyllum extract has obvious effects on controlling blood glucose and reducing the symptoms of polydipsia, polyphagia, and polyuria in diabetes. Gynostemma pentaphyllum extract has been gradually applied in clinical practice.
- Yeo JY et al.found that gynostemma pentaphyllum polysaccharides can significantly reduce blood glucose levels by altering the activity of glucose metabolic enzymes.
- Zhang HJ et al. found that GpM could significantly reduce insulin resistance parameters and increase glycogen concentration in the liver.
- Huang Ping et al. reported that after patients with type 2 diabetic nephropathy took gynostemma extract, their blood lipid was decreased and their renal function was improved significantly, thereby reducing the amount of urinary protein in patients.
Antioxidant and Anti-aging
- Gynostemma extract significantly prolongs the life of normal cells. It can inhibit lipid peroxide, reduce Ca2+ influx, and restrain cell apoptosis induced by glutamate, thereby making the weak healthy and energetic.
- Gypenosides play an anti-glutamate oxidation role in immature cortical cells, thus inhibiting the apoptosis of immature cortical cells.
- Gynostemma pentaphyllum saponins can also reduce the accumulation of peroxides in cells, decrease the consumption of GSH and increase the intracellular GSH content. Gynostemma pentaphyllum extract can delay natural aging by improving SOD activity and reducing free radical activity in blood.
Interactions with medications
- Medications that lower the immune system
- Interaction Rating: Use this combination sparingly.
- Gynostemma extract can increase the activity of the immune system and decrease the effectiveness of medications. Consult with your health provider, when you take it.
- The common Medications that can decrease the immune system listed below:
- sirolimus (Rapamune), prednisone (Deltasone, Orasone), muromonab-CD3 (OKT3, Orthoclone OKT3), basiliximab (Simulect), corticosteroids (glucocorticoids), azathioprine (Imuran), mycophenolate (CellCept), tacrolimus (FK506, Prograf), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), and others
- Anticoagulant / Antiplatelet drugs
- Interaction Rating: Be cautious with this combination.
- Jiaogulan extract can slow blood clotting. It will increase the chances of bruising and bleeding if you take Jiaogulan extract along with medications that slow clotting. Confirmed with your health provider, when you plan to take it.
- The common medications that can slow blood clotting:
- ticlopidine (Ticlid), aspirin, heparin, enoxaparin (Lovenox), warfarin (Coumadin), dalteparin (Fragmin), indomethacin (Indocin), and others.
Applications & Uses
- Markets
- Food & Nutrition Applications
Properties
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 1791.83 | - | - |
Technical Details & Test Data
- Specification
80% 90% 98%
Safety & Health
- Safey Concerns
- Many clinical trials proved that Gynostemma extract is POSSIBLY SAFE when taken orally short-term (up to 120 days). While the safety of long-term use is not known. Most people who take Gynostemma extract don’t experience problematic side effects. But some users may have side effects such as increased bowel movements and severe nausea.
- Special Precautions & Warnings:
- Pregnancy and suckling period: Jiaogulan is POSSIBLY UNSAFE when taken during pregnancy. As one of the chemicals in jiaogulan extract has been linked to possible congenital disabilities.
Packaging & Availability
- Packaging Type