Products in Excipients: Tablet Coating

Kollicoat® SR 30D is a versatile pharmaceutical and nutraceutical solution. Comprising polyvinyl acetate, it functions as a binder, controlled release agent, film former, matrix-forming agent, sustained release agent, and taste-masking agent. Specifically designed for oral and topical applications, this liquid product revolutionizes drug delivery and care solutions in healthcare and pharma. With cutting-edge technologies in pharmaceuticals and nutraceuticals, Kollicoat® SR 30 D ensures optimal performance as it seamlessly integrates into various formulations.

Kollicoat® MAE 100-55 is a versatile pharmaceutical and nutraceutical ingredient. Comprising Acrylates Copolymer and Methacrylic Acid Ethyl Acrylate Copolymer in a 1:1 ratio, it excels as an enteric coating system, filler, film former, matrix-forming agent, and solubilizer. In powder form, this technology caters to oral drug delivery and care solutions. Ideal for healthcare and pharma applications, Kollicoat® MAE 100-55 ensures efficient and reliable performance in diverse formulations.

Kollicoat® MAE 100 P is available in powder form, plays a multifaceted role as an enteric coating system, filler, film former, matrix-forming agent, and solubilizer. Its versatile applications span various dosage forms, including tablets, pellets, capsules, soft gels, and dispersions in the healthcare and pharma markets, particularly in oral drug delivery solutions.

Kollicoat® MAE 30 DP is a methacrylic acid ethyl acrylate copolymer (1:1) designed for pharmaceutical and nutraceutical applications. As an enteric coating system and film manufacturer, it excels in drug delivery and care solutions within the healthcare and pharma industries. Available in a dispersion form, Kollicoat® MAE 30 DP is specifically tailored for oral applications, showcasing its versatility in providing effective and reliable solutions in pharmaceutical and nutraceutical technologies.

Kollicoat® SR 30 D is an aqueous dispersion with a solids content of 30%. The low viscosity product has a weak characteristic odor and a milky white or slightly yellowish appearance. The dispersion consists of about 27% polyvinyl acetate, 2.7% povidone and 0.3% sodium lauryl sulfate. Kollicoat® SR 30 D is miscible with water in any ratio while retaining its milky-white appearance. Mixing the product with ethanol or isopropyl alcohol in a 1:5 ratio produces a slightly turbid and somewhat viscous solution, a solution in acetone is more turbid. On addition of further organic solvents the polymer precipitates out but then dissolves when further solvent is added. It is insoluble in dilute alkaline or acidic solutions.

Kollicoat® MAE 100-55 is a white redispersible powder with a faint characteristic odor. The product contains 0.7% sodium lauryl sulfate (USP) and 2.3% Polysorbate 80 (Ph. Eur.) as emulsifying agents. The fatty acids used in the manufacture of Polysorbate 80 are of vegetable origin. Kollicoat® MAE 100-55 is a weakly acidic copolymer that dissolves at a pH above 5.5. Kollicoat® MAE 100-55 dissolves in methanol and ethanol to yield clear to slightly cloudy solutions. It is also soluble in dilute alkaline solutions.

BIOGRUND’s ready-to-use printing ink BonuPrint® is a fine, homogenous, liquid pigment dispersion for solid oral dosage forms, available as an organic or aqueous solution.

METOLOSE® SM 4 consists of methyl cellulose (USP, JP, EP) and three substitution types of hydroxypropyl methyl cellulose (hypromellose USP, JP, EP) each available in several grades differing in viscosity.

METOLOSE® SR 90SH-100000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-4000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-15000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

TYLOPUR® 645 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

TYLOPUR® 606 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

PHARMACOAT® 603 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. It is easy to use it as a film coating material that provides an excellent finish

PHARMACOAT® 606 is a binder, it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, PHARMACOAT®® replaces gelatin in hard capsule manufacturing. It is also used as taste making agent for bitter tasting drugs.

TYLOPUR® 605 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

TYLOPUR® is a versatile hypromellose, compliant with USP, JP, EP. TYLOPUR® 60SH-50 provides a genuine consistency in Sustained release (matrix tablets). It also can be used as thickener in aqeous solution .It is also a good suspending agent in colloidal solution.

METOLOSE® SR 90SH-100SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-22 is suitable for direct compression.

HPMCP is a monophthalic acid ester of hypromellose.HP-50 is enteric coating agent soluble at lower pH

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-32 is suitable for wet granulation, pellet extrusion and layering.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-21 is suitable for wet granulation.

HPMCP is a monophthalic acid ester of hypromellose.HP-55S is enteric coating agent with greater strength and higher acid resistance due to its high molecular weight

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-31 is suitable for wet granulation, pellet extrusion and layering.

HPMCP is a monophthalic acid ester of hypromellose.HP-55 is a regular grade enteric coating agent.

AquaPolish® TC is a combination of HPMC, HPC and other cellulose ethers with taste masking additives. Due to the further additives, which form a hardly soluble film, a tastemasking is achieved.

BIOGRUND’s one-step film coating system AquaPolish® OM perfectly masks bad and strong smelling actives (e. g. herbal extracts). Sealing these characteristics by using AquaPolish® OM enables a pleasant application for the consumer and increases patient compliance. It provides a protective and economical coating on tablets, pellets, granules and capsules without influencing the disintegration time.

BIOGRUND’s sugar-coating system IsuPolish® S provides a sugar dragée with excellent taste and odor masking properties. Furthermore the dragée gets a smooth and glossy appearance.

BIOGRUND provides a wide range of ready-to-use film coating products which includes AquaPolish® MS. It's a moisture sealing product. It provides a protective and fast soluble film on tablets, pellets, granules and capsules. It is a combination of selected film-forming cellulose ethers with plasticizing and coloring additives. The use of hydrophobic excipients gives excellent protection against moisture. The product is designed to improve the coating process and can be applied using conventional or modern coating equipment. It is a homogeneous, dry-milled, powdered compound, developed for the coating of all kinds of solid dosage forms. It is easily soluble and a reproducible high-quality film coating can be achieved. Clear, white and colored preparations can be tailor-made according to customer requirements. Contact us for more information.

CompactCel® FLO is a flow agent for loosening powder mixtures and improving flowability. The ready-touse powder compound replaces synthetic additives such as silicon dioxide. It prevents bridge formation during flow from hopper and provides a clean funnel flow of the powder mass to be processed during both tableting and capsule filling.

BIOGRUND’s one-step tabletting agent CompactCel® SIL provides an easy to use, granulated and homogeneous compound of Silica and PVP/ NaCMC or HPC/NaCMC, which acts as a perfect dry binder granulate.

BonuCel® provides easy-to-use cellulose ethers for pharmaceutical and nutritional products. The main application of Hypromellose is film coating. The fine, homogeneous blends of selected high quality cellulose ether polymers provide excellent film forming properties and sustained release profiles. A wide range of standard viscosities is offered to deal with different application requirements. Additionally, BIOGRUND offers an exclusive service by finely adjusting viscosities.