Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
Features & Benefits
- Benefit Claims (Health)
- Food Ingredients Features
- Stability Advantage
- DE111® remains viable under a wide temperature range, and doesn’t require refrigeration.
- It also survives passage through the acidic environment of the stomach.
- DE111® remains viable under a wide temperature and pH range, the probiotic is ideal for use in supplements, foods and beverages.
- In stability testing, DE111® experienced virtually no loss of colony forming units (CFU) over 24 months, when stored at room temperature (25°C).
- DE111® can also stand up to many food and beverage processing and storage conditions.
DE111® Shelf Stability
- DE111® remains stable over 24 months at 25°C and 40% relative humidity.
Activity (CFU/G) vs TIME (months)
DE111® Temperature Stability
- DE111® viability is maintained under temperatures up to 100°C for up to 5 minutes.
DE111 CFU/G vs TIME (minutes)
DE111® pH Stability
- DE111® viability is maintained under a wide pH range for a period of three weeks.
- Product Benefits
- DE111®has been extensively studied in clinical trials, which have demonstrated positive effects on digestive and immune health parameters in adults and young children, as well as factors related to muscle recovery.
- DE111® grows quickly and most optimally at 37°C (body temperature), while some other spores grow best at temperatures above or below the human body, taking up to 72 hours to begin growing. The sooner it grows, the greater the likelihood for functional benefits.
- Per serving, the cost of adding a clinically supported amount of DE111® to food and beverage products is more effective than many other spore probiotics on the market.
- The probiotic experts at ADM will work with you through the technical aspects of adding DE111® to your products, including CFU and stability testing.
- Contains probiotic cultures
- Supports healthy gut function
- Promotes digestive health
- Supports regularity
- Supports immune health
- Supports exercise recovery
- Supports digestive and immune health in young children
- Clinical Results
Digestion
- A clinical study evaluating the effect of DE111® (5 billion CFU) on digestive health demonstrated DE111® was able to maintain healthy levels of cholesterol, glucose and triglycerides, indicating that DE111® may be involved in normal breakdown of complex carbohydrates, sugars and fats.
Immune Function
- In a study involving 44 participants aged 20-62, researchers observed after four weeks of daily consumption of the probiotic DE111® at 1 billion CFU, a significant decrease from baseline in the basal levels of several immune cell populations, including CD3+ T cells and NKT cells.
- Moreover, the probiotic group showed an increased immune response in cells with an induced inflammation (ex vivo).
- The results indicate that DE111® may modulate the immune system through action on both innate (rapid response) and adaptive (slow response) immune cell types.
Regularity
- A clinical study showed an improvement in stool quality for participants taking DE111® (1 billion CFU) when compared to participants taking the placebo.
- Over the course of the study, the proportion of normal stools increased from 37% to 43% in the DE111® group, while remaining the same in the placebo group.
Children's Health
- In a study involving 91 children aged 2 to 6, researchers found that daily consumption of the probiotic DE111® positively modulated “the gut microbiome profile without changing the overall microbiome equilibrium.”
- After 8 weeks of daily consumption at 1 billion CFU, the researchers observed an “increase in alpha-diversity at the phylum level, suggesting an expanded functional diversity of the microbiome” compared to that of the children in the placebo group.
- Specifically, the study authors report, there were nine differentially abundant taxa at the genus level found in the probiotic group, six (of the phylum bacteroidetes) grew in abundance while three (of the phylum firmicutes) were reduced.
- This modulation of the firmicutes/bacteroidetes ratio of the microbiome in children taking B. subtilis DE111® may be a positive indication for healthy gut function.
- In a study involving 81 children aged 2 to 6, researchers found that children taking DE111® had improvements in measures of gastrointestinal wellness compared to the placebo group.
Body Composition and Recovery
- In a study involving female collegiate athletes during offseason training, researchers found that DE111® (1 billion CFU), in conjunction with a protein drink supplement, was associated with changed body composition with strength training.
- The results of the study showed that compared to the placebo, the probiotic DE111® produced statistically significant reduction of body fat percentage.
- In a study involving male collegiate athletes during offseason training, researchers found that supplementation with DE111® (1 billion CFU), in conjunction with adequate post-workout nutrition, was associated with a statistically significant reduction of tumor necrosis factor alpha (TNF- ), a cytokine that indicates inflammatory response.
Applications & Uses
- Markets
- Applications
- Food & Nutrition Applications
Properties
- Physical Form
Regulatory & Compliance
Packaging & Availability
- Product Availabity
DE111® is available as a powder in 5kg and 25kg drums