Knowde Enhanced TDS
Identification & Functionality
- Cosmetic Ingredients Functions
- Technologies
- Product Families
- Compositional Breakdown
Product Chemical Compound Breakdown Cas No. EINECS No. Isocil® PC 5-Chloro-2-methyl-4- isothiazolin-3-one 26172-55-4 247-500-7 2-Methyl-4-isothiazolin3-one 2682-20-4 220-239-6 Magnesium Chloride 7786-30-3 232-094-6 Magnesium Nitrate 10377-60-3 233-826-7 Water 7732-18-5 231-791-2 Chemical Compound Breakdown % 5-Chloro-2-methyl-4-isothiazolin-3-one 1.15% min. 2-Methyl-4-isothiazolin-3-one 0.35% min. Magnesium nitrate 21.0–25.0% Magnesium chloride 0.4–0.8% Water 73.8–78.2%
Features & Benefits
- Benefit Claims
- Key Attributes
- MI/CMI blend
- Broad spectrum preservation
- Easy to use liquid product
- Compatible with cationic, anionic, nonionic systems
- Compatible and soluble in most personal care raw materials
- Cost effective
- Clear liquid aqueous solution
- Has a wide range of global regulatory approval
- Traditional Efficacious Preservation
- General Information
Not allowed for oral hygiene and lip products or in preparations for children under the age of 3
Applications & Uses
- Markets
- Applications
- Baby Care Applications
- Bath & Shower Applications
- Color Cosmetic Applications
- Hair Care Applications
- Personal Hygiene Applications
- Skin Care Applications
- Sun Care Applications
- Wipes, Tissue & Towel Applications
- Use Level
- 0.05-0.1% (Regional limits apply)
- Application pH Range
- 3–9
- Applications
- Anhydrous
- Baby care
- Baby wipes
- Body wash
- Conditioner
- Cream
- Deo/ Anti-Perspirant
- Eye creams/gel
- Eye shadow
- Face Lotion
- Face wipes
- Facial Cream
- Foundation
- Hair gel
- Hand soap (non anti-bac)
- Lotion
- Make up remover
- Mascara
- Oil in Water
- Powder
- Shampoo
- Suncare
- Toner
- Water in Oil
- Formulation Recommendations
- Miscible in water, glycols, most personal care solvents
- Reducing agents, amines and strong nucleophiles will reduce activity of MCI/MI
- Surfactants should be checked for residual bisulfite before addition
- When used with amines, pH should be below 6 before addition
- Should be added during the cool down phase of processing, at temperature of 50°C or below
- Wide range pH: 3–9
- Product pH (as is) is 3.0; should be handled with care due to acidity
Properties
- Physical Form
- Odor
- Mild
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Global Regulatory
Europe
- Listed in Annex V to Regulation EC/1223/2009
- Not permitted for leave-on products. Maximum use level of 0.0015 % CMI/MI for rinse-off applications
Japan
- Listed in the positive list
- Max use level of 0.01% CMI/MI for rinse-off
- Not permitted in leave-on
US
- Approved by PCPC for both rinse-off and leave-on applications
- Max level of 0.00075% CMI/MI (7.5 ppm active ingredients) in leave-on products
- Max level of 0.0015% CMI/MI (15 ppm active ingredients) in rinse-off products
Technical Details & Test Data
- Efficacy
Microbiological Challenge Studies
Studies were run using different concentrations of Isocil® PC in various formulations to see efficacy against various bacteria, yeast and fungi compared to other commercial isothiazolinones. All samples were inoculated at the beginning of the study, sampled at 24 hours, 3, 7, 10, 14, 21 and 28 days.- Shampooo Formula
Ingredient % wt/wt CARSONOL_ SLES 35.0% CARSONOL_ TLS 25.0% CARSAMIDE_ CA 3.0% Water (deionized) 36.0% Polypro 5000 1.0% Preservative q.s. Total 100.0% - Isocil® PC vs. Competitive Isothiazolinone – Shampoo Mixed Inoculum-Bacteria*
CFU – Contact Time (Days) Preservative % 0 1 3 7 10 14 28 None 7.1x10^6 3.4x10^6 9.0x10^6 3.4x10^7 4.2x10^7 3.4x10^7 2.3x107 Isocil® PC 0.05 5.5x10^6 3.1x10^4 3.0x10^3 <10 <10 <10 <10 Isocil® PC 0.10 7.8x10^6 7.8x10^4 3.0x10^3 <10 <10 <10 <10 Competitor 0.05 7.1x10^6 3.5x10^4 1.0x10^3 <10 <10 <10 <10 Competitor 0.10 6.1x10^6 5.0x10^4 2.0x10^3 <10 <10 <10 <10 * Mixed Inoculum consists of P. aeruginosa, S. aureus, and E. coli
- Isocil® PC vs. Competitive Isothiazolinone – Shampoo Mixed Inoculum-Fungi**
CFU - Contact Time (Days) Preservative % 0 1 3 7 10 14 28 None 8.0x10^5 3.0x10^5 6.0x10^5 4.0x10^5 3.0x10^5 3.0x10^5 3.0x10^5 Isocil® PC 0.05 1.0x10^6 2.2x10^4 3.0x10^3 <10 <10 <10 <10 Isocil® PC 0.10 9.0x10^5 3.3x10^4 3.0x10^3 <10 <10 <10 <10 Competitor 0.05 8.0x10^5 3.0x10^4 1.0x10^3 <10 <10 <10 <10 Competitor 0.10 8.0x10^5 1.3x10^4 2.0x10^3 <10 <10 <10 <10 *Mixed Inoculum consists of C.albicans and A. niger
Packaging & Availability
- Country Availability
- Regional Availability