Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- CAS No.
- 18472-51-0
- EC No.
- 242-354-0
- Technologies
- Product Families
- Compositional Breakdown
Chemical Compound Breakdown % Chlorhexidine Digluconate 19–21% Water 79–81%
Features & Benefits
- Labeling Claims
- Key Attributes
- In compliance with USP requirements
- Strong bactericide
- Not sensitizing
- Mild to skin
- Can be used in a variety of personal care applications
- Excellent antibacterial performance
- Cationic antimicrobial
- Recognized compatibility with mucous membranes
Applications & Uses
- Markets
- Applications
- Application Format
- AP/Deo Applications
- Baby Care Applications
- Bath & Shower Applications
- Color Cosmetic Applications
- Hair Care Applications
- Oral Care Applications
- Personal Hygiene Applications
- Skin Care Applications
- Sun Care Applications
- Wipes, Tissue & Towel Applications
- Use Level
- 0.25–1.5%
- Application pH Range
- 6-8
- Formulation Recommendations
- Not for use at temperature > 70°C
- Effective at pH 5–8 (optimum between 5.5–6.5)
- Typically compatible with cationic and nonionic surfactants, although recommend to confirm compatibility in each specific case
- Incompatible with anionic surfactants
- Not compatible with anionics including soaps, gums, carbomers
- Sensitive to inorganic substances (borate, carbonate, chloride, citrate, phosphate and sulfate)
- Can be affected by UV light
- Storage in a refrigerator is recommended
- Applications
- Baby care
- Baby wipes
- Body wash
- Conditioner
- Cream
- Deo / Anti-Perspirant
- Eye creams/gels
- Eye shadow
- Face lotion
- Face wipes
- Facial cream
- Foundation
- Hair gel
- Hand soap (non anti-bac)
- Lipstick/Gloss
- Lotion
- Makeup remover
- Mascara
- Oil in Water
- Oral Care
- Powder
- Shampoo
- Sun Care
- Toner
- Water in Oil
Properties
- Physical Form
- Odor
- Mild
- Appearance
- Clear liquid
- Soluble in
- Water
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Global Regulatory
Europe
- Approved under Annex V to Regulation EC/1223/2009
- Max concentration of 0.3 % as expressed as chlorhexidine
Japan
- No limit for rinse-off products not coming into contact with mucous membranes
- 0.05 % maximum for leave-on products not coming into contact with mucous membranes
- 0.05 % maximum for products coming into contact with mucous membranes
US - U.S. (CIR opinion) and Canada, max concentration of 0.2 %
- In compliance with USP requirements
Technical Details & Test Data
- Efficacy
MICs were conducted on Spectradyne™ against bacteria, yeasts and molds with results
Gram-Negative ppm Spectradyne™ Escherichia col 1.0–5.0 Salmonella dublin 2.5–15.0 Salmonella typhi 1.6 Salmonella typhosa 2.5 Salmonella pullorum 7.0 Salmonella typhimurium 14.0 Shigella flexneri 1.5 Shigella sonnei 1.6 Klebsiella aerogenes 1.5–12.5 Klebsiella pneumoniae 6.2 Enterobacter cloacae 2.5–3.2 Proteus mirabilis 25.0–100.0 Proteus morgani 25.0–43.0 Proteus vulgaris 7.0–25.0 Proteus rettgeri 3.0–100.0 Pseudomonas fluorescens 10.0 Pseudomonas aeruginosa 3.0–60.0 Aeromonas aerogenes 12.5 Vibrio cholerae 7.0 Gram Positive Bacillus subtilis 1.4–3.0 Bacillus cereus 3.0 Bacillus megatherium 1.0 Clostridium welchii 70.0 Clostridium novyi 1.8 Clostridium tetani 7.0 Clostridium botulinum 3.5 Clostridium perfringens 14.0 Streptococcus pyogenes 0.6–5.0 Streptococcus faecalis 1.4–3.0 Streptococcus mutans 0.1 Streptococcus lactis 1.4 Streptococcus pneumoniae 7.0 Staphylococcus aureus 1.0–2.0 Staphylococcus albus 1.0 Staphylococcus epidermidis 5.0 Corynebacterium diphtheriae 5.0 Corynebacterium acne 10.0 Micrococcus luteus (Sarcina lutea) 2.0 Mycobacterium tuberculosis 0.7–6.0 Yeasts ppm Spectradyne™ Candida albicans 7.0–15.0 Trichophyton mentagrophytes 2.5 Trychophyton tonsurans 14.0 Microsporum audouini 14.0 Microsporum gypseum 14.0 Microsporum canis 18.5 Saccharomyces ellipsoideus < 50 Saccharomyces cerevisiae < 50 Schizosaccharomyces octosporus 125 Schizosaccharomyces pombe < 50 Molds ppm Spectradyne™ Aspergillus versicolor 75 Aspergillus niger < 200 Rhizopus nigricans 175 Trichoderma viride 125 Mucor plubeus 125 Penicillium notatum 200 Penicillium roqueforti 150 Sporendonemma spp. < 50 - Lotion
Phase (A) % Phase (B) % Water qs Hydroxyethylcellulose 1.5 Urea 5.00 — — Sorbitan Monostearate 2.00 — — Caprylic/ Capric Triglyceride 20.00 — — PEG 1750 Monostearate 1.50 — — Glyceryl Monostearate 2.00 — — Decaglycerol Decaoleate 5.00 — — Test Organism Unpreserved Control Test – Spectradyne™ (0.4%) Initial Challenge Rechallenge Initial Challenge Rechallenge 24 Hrs 1 Week 28 Days 28 Days 24 Hrs 1 Week 28 Days 28 Days S. aureus 1.4 x 10^6 1.1 x 10^6 <10 8.0x 101 1.9x10^2 <10 <10 <10 K. pneumoniae + E. gergoviae 6.4 x 10^5 7.1 x 10^4 <10 <10 5.3x10^4 <10 <10 <10 P. aeruginosa + B. cepacia 5.1 x 10^5 1.2 x 10^5 <10 <10 <10 1.4 x102 <10 <10 C. albicans 9.7 x 10^4 5.0 x 10^1 <10 <10 9.4 x10^4 2.8 x 102 7.0 x 103 7.0 x 10 Mixed Molds 9.0 x 10^4 8.3 x 10^4 2.3 x 10^4 1.3 x 103 1.4 x 10^3 2.8 x 10^2 7.0 x 10^3 7.0 x 10^1 - Test Result
Packaging & Availability
- Country Availability
- Regional Availability