Knowde Enhanced TDS
Identification & Functionality
- Active Component
- INCI Name
- Ingredient Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Product Families
Features & Benefits
- Benefit Claims
- Benefit Claims (Health)
- Food Ingredients Features
- Product Highlights
Pueraria mirifica grows only in the rich soils of the high-altitude rainforests of Thailand and has been used by the Thais for a millennium as a rejuvenator and revitalizer to help offset some of the effects of aging. Puresterol®, developed by Bio-Botanica, is the only patented, specially processed and highly active compound of Pueraria mirifica available in the market today (US Patent # 7,658,955, 2023).
Applications & Uses
- Applications
- Food & Nutrition Applications
- Skin Care Applications
Regulatory & Compliance
- Certifications & Compliance
Technical Details & Test Data
- Clinical Studies
- A third-party contract research organization (CRO) conducted clinical trials of Puresterol® in two different serum formulations under sponsorship by Bio-Botanica. In each trial, 21 subjects in different groups applied a serum in the morning and night for 28 days. The CRO used a state-of-the-art 3D structured-light scanner and software to precisely measure the area, length, and depth of crow’s feet and forehead wrinkles at day 0 and day 28. In addition, subjects were asked to evaluate their assessment of their treatment.
- The first, placebo-controlled trial indicated Puresterol® in a serum had a statistically significant greater reduction of the depth of Crow’s feet wrinkles when compared to placebo (p<0.05). The Puresterol® containing serum reduced the area of Crow’s feet wrinkles (p<0.01), the length of Crow’s feet wrinkles (p<0.01), and the depth of forehead wrinkles (p<0.01) from day 0 to day 28 in a statistically significant manner.
- A follow up study with a different amount of Puresterol® in a serum indicated similar results with a statistically significant reduction in area of Crow’s feet wrinkles (p<0.05), length of Crow’s feet wrinkles (p<0.0001) and area of forehead wrinkles (p<0.05) from day 0 to day 28.
- Additionally, over 80% of subjects in each of the Puresterol® groups indicated that at day 28, the Puresterol® based serum left the contours of their face appearing smoother. These results support a previous in vitro trial sponsored by Bio-Botanica® which found varied concentrations of Puresterol® inhibited Collagenase activity accordingly.
- Collagenase is an enzyme known to break down collagen and elastin and possibly lead to wrinkle formation.
- These studies support the use of Puresterol® as a cosmetic. Bio Botanica also offers Puresterol to companies for use in dietary, beauty from within, food, and beverage consumer packaged goods.