DEP

DNT (Starpharma Group) Brand

Products:3

Benefits of DEP® is used to improving efficiency, reducing toxic side effects of drugs, extending the duration of activity of the drug in the body, targeting drugs to Organs, tissues or molecular receptors, increasing solubility.

View All DEP Products

DEP® docetaxel

Certifications & Compliance:cGMP

DEP® docetaxel is water-soluble and does not require surfactant such as polysorbate 80 for dissolution. Drug substance is readily manufactured at scale using standard chemistry under cGMP.

DEP® cabazitaxel

Applications:Medical, Other Medical Applications
Product Families:APIs & Raw Materials, Active Pharmaceutical Ingredients (APIs)

DEP® cabazitaxel is Starpharma’s detergent-free version of cancer drug, Jevtana®, which is marketed by Sanofi Aventis to treat advanced prostate cancer, and is also under clinical development for a range of other cancer types, including testicular, ovarian, breast, bladder, and head and neck.

DEP® irinotecan

Applications:Medical, Other Medical Applications
Product Families:APIs & Raw Materials, Active Pharmaceutical Ingredients (APIs)

DEP® irinotecan is a novel, patented nanoparticle formulation of SN-38, the active metabolite of irinotecan, delivered using Starpharma’s proprietary DEP® technology. DEP® irinotecan has shown a number of benefits compared to the original form of irinotecan, including significant improvements in anti-cancer efficacy and improved survival in multiple human cancer models. DEP® irinotecan is the third DEP® product to enter the clinic from Starpharma’s internal portfolio.

Knowde Brand Summary

Identification

Technologies: Pharmaceuticals & Nutraceuticals
Product Families: Pharmaceutical Actives & Precursors
Active Pharmaceutical Ingredients (APIs)
Pharma & Nutraceuticals Functions: Anti-Cancer Agent

Applications & Uses

Markets: Healthcare & Pharma
Applications: Medical
Other Medical Applications

Knowde Brand Highlights

Benefits of DEP®: Benefits of DEP^® dendrimer drug delivery include:

Improving Efficacy
Animal studies showed that DEP^®docetaxel was significantly more efficacious than docetaxel in a breast cancer model. The improved efficacy is understood to be due to a longer circulating half-life, extended release of the docetaxel and targeting of the dendrimer-docetaxel construct to the tumour tissue.

Reducing toxic side effects of drugs
Conversely dendrimers can be used to restrict the circulation of the drug in the body. This may avoid side effects, or may allow a higher dose of the drug to be administered than would otherwise be acceptable.

Extending the duration of activity of the drug in the body
Dendrimers can protect drugs from degradation and clearance. This may mean that an improved dosing regimen can be pursued, for example, replacing a daily infusion with a once weekly injection.

Targeting drugs to Organs, Tissues or Molecular Receptors
Dendrimers have been used to actively or passively target a drug to particular destination in the body.

Increasing Solubility
By joining the drug to a dendrimer construct, very large increases in drug solubility have been achieved, which can enhance the “bioavailability” of the drug.It can also avoid the need for the use of problematic and potentially dangerous additives in drug formulations, helping to improve the safety profile of the active.