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HTBA Diosmin is another flavonoid used as a venotonic for the chronic treatment of CVD, varicose veins, hemorrhoids, spider veins, and heavy leg syndrome. Like HTBA Diosmetin, it is a GMP-certified API with an EcoVadis certification, contributing to blood circulation and vascular health.

Chemical Name: Diosmin

CAS Number: 520-27-4

Certifications & Compliance: Certificates of Suitability (CEP), ECOVADIS, European Pharmacopeia (Ph. Eur.), FAMI-QS, FSSC 22000, GMP, Halal, Hazard Analysis Critical Control Point (HACCP), ISO 14001, ISO 9001, Kosher, REACH (Europe), United States Pharmacopeia (USP)

Labeling Claims: Additive-free, Allergen-free, Gluten-free, Halal, Kosher, Non-GMO, Solvent-free, TSE-free

Synonyms: 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside, Diosmetin 7-Neohesperidoside, Diosmetin 7-O-Rutinoside, Diosmine, Neodiosmin

Knowde Enhanced TDS

Identification & Functionality

Chemical Name

Features & Benefits

Applications & Uses

Properties

Physical Form
Appearance
Greyish-yellow or light yellow, hygroscopic powder
Partially Soluble in
Water
Soluble in
Dimethyl sulphoxide
Insoluble in
Ethanol (96 percent)
Typical Properties
ValueUnitsTest Method / Conditions
Iodinemax. 0.1%
Acetoisovanillonemax. 0.5%
Hesperidin (B)max. 4%
6-iododiosmin (D)max. 0.6%
Linarin (E)max. 3%
Diosmetin (F)max. 2%
Unspecified Impuritiesmax. 0.4(each impurity)%
Totalmax. 8.5%
Watermax. 6.0%Karl Fischer
Sulphated ashmax. 0.2%
Assay90.0 - 102.0%
Tapped Densitymax. 0.6g/ml
Microbiological Values
ValueUnitsTest Method / Conditions
Total Plate Countmax. 10³cfu/g
Total Yeast and Molds Countmax. 10²cfu/g
Enterobacteriaemax. 10²PNB/g
SalmonellaAbsence/10g
Escherichia coliAbsence/g
Staphylococcus aureusAbsence/g
Related Substances
ValueUnitsTest Method / Conditions
Isorhoifolin (C)max. 3%
Note

Dissolves in dilute solutions of alkali hydroxides.

The product complies the specification appearing in current Eur. Ph. Monograph.

Comments

The product complies the specification appearing in current Eur. Ph. Monograph.

Regulatory & Compliance

Technical Details & Test Data

Identification

A. Infrared absorption spectrophotometry. Comparison: diosmin CRS.
B. Examine the chromatograms obtained in the assay.
Results: the principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a).