Knowde Enhanced TDS
Identification & Functionality
- Ingredient Name
- Food Ingredients Functions
- Pharma & Nutraceuticals Functions
- CAS No.
- 520-36-5
- Molecular formula
- C15H10O5
- Ingredients
- Apigenin
- Product Families
- RICH SOURCES OF APIGENIN
Although it is found in many fruits, vegetables and herbs, the amount of it varies. The richest natural sources are: Parsley, Celery, Other spices such as rosemary, oregano, thyme, basil and coriander, Chamomile, Cloves, Lemon Balm, Artichokes and Spinach, Peppermint, Red wine and Licorice.
Chamomile extract, parsley and celery (Apium graveolens) are the main botanical sources of bulk apigenin to be used in supplement formula. However, apigenin from the two plants are different as well. The apigenin content in chamomile is very low, about 1%, and low standardized extract of apigenin like 1.2%, 3% are proper from chamomile extract, while high potency of apigenin from celery extract or Apium graveolens is the best source. The apigenin 98% from chamomile is much more expensive than from Apium graveolens. However, the cheapest 98% apigenin source is from pure synthesis. All these specifications are available from Herb Nutritionals Co., Ltd.
- Specifications
98%, 1%
- Other Names
Apigenine; biapigenin, Chamomile; Apigenol; Spigenin; Versulin; 4',5,7-Trihydroxyflavone; C.I. Natural Yellow 1.
- Source
Chamomile, Matricaria recutita, Asteraceae, parsley, celery, Matricaria chamomilla, Apium graveolens, purely Synthesis
Features & Benefits
- Food Ingredients Features
- Benefits of taking apigenin supplements
Like most flavonoids, apigenin has anti-inflammatory, anti-tumor, anti-spasmodic properties, and acts as an antioxidant. The most widespread research has been for its potential to fight cancer.
Researchers are investigating its potential to promote cellular health within various tissues. The most promising work is being done with regard to the prostate, but research shows benefit within other tissues as well. As the investigations continue, Apigenin’s potential as a powerful agent for human health just keeps adding up. We’re pleased to be among the first to bring you a pure, nature-identical Apigenin supplement.
Apigenin and Cancer Prevention
Apigenin may reduce the risk of prostate, breast, stomach and bladder cancer as well as leukemia.
Apigenin and stress and anxiety release
Chamomile tea has long been a folk remedy for dealing with stress and anxiety, and it turns out that the active ingredient in chamomile is apigenin. Several animal studies show that apigenin modulates GABA receptors in the brain. This is significant because GABA is the brain’s primary inhibitory neurotransmitter, which means that when it’s stimulated, you feel relaxed. In fact, most drug-based sleeping pills work by also interacting with GABA receptors in the brain. But apigenin has the notable advantage over drugs in that it provides relaxation effects minus sedation. It’s also a natural anti-depressant. The relaxation effects attributed to red wine and lemon balm may also be from their content of apigenin, although the alcohol content of red wine also plays a role in this effect.
Apigenin and Lower Blood Pressure
Celery is often recommended as a natural way to help lower elevated blood pressure. Celery is rich in apigenin, again thought to be the active ingredient for this effect, too.
Apigenin and anti-inflammatory effects
One way that it does this is by inhibiting an enzyme called COX-2 that converts arachidonic acid, a fatty acid, into eicosanoids that are the direct cause of some types of pain and inflammation. Most commerical analgesics, such as aspirin and non-steroidal anti-inflammatory drugs work through the same mechanism,although apigenin doesn’t produce the side effects of these drugs, including ulcers, cardiovascular disease, and possible kidney failure with long-term, high dose, usage. Since cancer has an inflammatory component, it’s not surprising that apigenin has been shown in several studies, mostly involving animals, to prevent several types of cancer. These include cancers of the lungs, ovaries,prostate, thyroid, and pancreas. Apigenin also blocks the activity of the HER-2 gene, which promotes breast cancer in many women.
Apigenin and sports nutrition benefits
Apigenin is an inhibitor of CYP2C9 and CD38. CD38 is a NAD+ase which effectively reducesNAD+ levels in mitochondria. Inhibiting CD38 increases NAD+ that allows for increased sirtuin activation in the presence of a SIRT1 activator (results in the deacetylation and modulation of the activity of downstream SIRT1 targets). Thus, more energy is gained with the presence of apigenin. Therefore, if there are supplements containg NAD+ or NADH, apigenin is recommended.
Bodybuilders would find apigenin useful because it’s a natural aromatase inhibitor. Aromatase is the enzyme that converts androgens, including testosterone, into estrogen. But the most interesting aspect of apigenin in relation to testosterone is shown in an upcoming study. Testosterone levels drop in most men beginning at about age 40. While there are various theories as to the cause of this hormonal decline, one plausible theory relates the drop in testosterone to a decrease of a protein synthesized in the testes, and wherever else steroid hormones are made in the body, including the brain and adrenal glands. This protein is called the steroidogenic acute regulatory protein or StAR. What StAR does is transport cholesterol, which is the raw material from which all steroid hormones are produced from, including testosterone, estrogen, and cortisol, from the outer mitochondrial membrane in cells to the inner membrane, where production of the hormones begins.
Applications & Uses
- Markets
- Food & Nutrition Applications
- Apigenin Dosage
There are no so many supplement formulas using apigenin ingredient, and scientific dosing guidance is not available. However, according to Swanson Ultra apigenin, there are two sources of apigenin, one is from grapefruit, and the other is from Chamomile Flower Extract. The apigenin derived from grapefruit is recommended to take one capsule (50mg apigenin per serving) from the label while for Chamomile Flower Extract (standardized to 1% apigenin), the recommended dosage is about 500mg. If you want to know about the dosage for 98% apigenin, please kindly send email to us, and our chemists will reply with scientific guidance.
Properties
- Appearance
- Little Yellow Powder
- Typical Properties
| Value | Units | Test Method / Conditions | |
| Molecular Weight | 270.24 | — | — |