Knowde Enhanced TDS
Identification & Functionality
- Chemical Name
- INCI Name
- Agrochemical Functions
- Cleaning Ingredients Functions
- Cosmetic Ingredients Functions
- Pharma & Nutraceuticals Functions
- CAS No.
- 142-18-7
- EC No.
- 205-526-6
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- HII Features
- Product Features
Glyceryl Monolaurate 90 % is a distilled glyceryl monolaurate. This unique, multifunctional compound can bring added elegance and utility to personal care and pharmaceutical products. When compared with standard "mono glycerides",Glyceryl Monolaurate 90 % has many more positive characteristics which are not typically found in just a single product. Some of these features are
- Stability to oxidation
- Low odor & pure white color
- Potent emulsification
- Superior emolliency
- Virtually no skin irritation
- Transdermal penetrating properties
- No pH effect on the skin
- Antimicrobial activity
Applications & Uses
- Markets
- Applications
- Application Format
- Bath & Shower Applications
- Home Care Applications
- I&I Cleaning Applications
- Oral Care Applications
- Personal Hygiene Applications
- Skin Care Applications
- Treatment Product Applications
- Wipes, Tissue & Towel Applications
- Use Level
- 0.1-5.0
- Product Applications
- In formulating, effective use levels can range between 0.1% and 5.0%, depending upon the application. Glyceryl Monolaurate 90 % should be added to a formulation so that it does not receive severe heating for prolonged periods.
- Glyceryl Monolaurate 90 % can be dispersed in water and dissolved in oil. Glyceryl Monolaurate 90 % solubility in glycerin and PG is limited to less than 5%. It would be highly soluble in ETOH, probably 10%-20%. Depending upon which phase Glyceryl Monolaurate 90 % is added, it will have an effect on the final viscosity and texture properties.
- Traditional alkyl glycerides have a monoglyceride level in the 35-45% range. Recently developed technolo-gy has lead to the production of Monolaurin with a monglyceride content above 90%. It has always been known that higher the monoglyceride content, the better the emulsification properties. In addition, the fatty acid composition of this unique product has been peaked to give greater than 98% lauric acid, re-sulting in a very pure glyceryl monolaurate that is available nowhere else.
- In a healing type ointment, Glyceryl Monolaurate 90 % can contribute to the promotion of wound heal-ing through the reduction of advantageous bacteria. Any ointment of this type aimed at burns, bites and cuts, will be enhanced.
- Numerous papers suggest that Glyceryl Monolaurate 90 % can be very useful in toothpastes and mouth rinses to mitigate the formation of "caries," thus reducing tooth decay. It also inhibits plaque build-up.
- Numerous papers site the improved transdermal penetration of drugs using Glyceryl Monolaurate 90 %. The addition of 10% Glyceryl Monolaurate 90 % can give a five-fold improvement in the drug's trans-dermal penetration.
- Another abstract of record suggests that Glyceryl Monolaurate 90 % demonstrates the effective promo-tion of topically applied drugs in the treatment of psoriasis by providing better topical adsorption with reduced loss of the relevant active. Glyceryl Monolaurate 90 % could make treatments less irritating, easier to apply, and more cost effective by extending product usage.
- The transesterification products of triglycerides and glycerin have a long history of use, particularly in the food industry as emulsifiers. Their safety and efficacy has been proven for years and they have achieved GRAS (Generally Recognized as Safe) status as designated by the U.S. Code of Federal Regula-tions.
Properties
- Comparison Properties
Some of the available data relevant to the antimicrobial activity of Glyceryl Monolaurate 90 % is given in the following two tables. In Table 1, Glyceryl Monolaurate 90 % is ranked against two common pre-servatives using gram-positive bacteria and yeast organisms.
Table 1
Comparison of antibacterial activity of glycerol monolaurate and common preservaties
Minimum Inhibitory concentration (μgm/ml) B. Subtil-lis B. Cereus S. Aure-us S. Cerevisae A. Niger C. Uti-lis --------------------------Gram+--------------------- ---------Yeast-------- Glycerol Monolaurate 90% 20 20 20 20 20 20 Butyl-hydroxybenxoate 400 200 200 200 400 200 Sorbic Acid 4000 4000 4000 4000 4000 4000 Gram positive organisms are generally associated with the semi-dry conditions found on surfaces such as skin. The control of these types of organisms is important when considering how many finished prod-ucts are used. Consumers using open jars of crèmes or lotions will often dip their fingers or an applicator into the product causing repeated exposure of the emulsion to gram positive microbes. Without sufficient preservation, microbial growth is augmented particularly along the sides of the container and the under-side of the cap.
Although Glyceryl Monolaurate 90 % is less effective against gram-negative organisms as compared with other traditional preservatives, its action can be potentiated by the addition of chelants such as EDTA, lactic, citric acid, and polyphosphates. In Table 2, a simple oil-in-water emulsion is challenged by the ad-dition of two gram-negative organisms where Glyceryl Monolaurate 90% is the emulsifier and preserva-tive. By itself, the emulsion is not preserved, but a small addition of EDTA effectively controls microbial growth. Note that additional methyl paraben is not effective; the synergistic action is due solely to the presence of EDTA.
Table 2
Preservatie effect of food-grade chemicals against gram-negative organisms in a glycerol monolaurate 90% lotion.At 24 h At 48 h At 1 week Preservative P. Aeruginosa E. Coli P. Aeruginosa E. Coli P. Aeruginosa E. Coli EDTA 0.1% Growth Growth Growth Growth No Growth 0.2% No Growth Slight Growth No Growth Slight Growth No Growth No Growth 0.3% No Growth Slight Growth No Growth Slight Growth No Growth No Growth Methylparaben 0.1% Growth Growth Growth Growth Growth No Growth 0.2% Growth Growth Growth Growth Growth No Growth 0.3% Growth Growth Growth Growth Growth No Growth EDTA + Methylparaben
0.1% + 0.1% Growth Growth Slight Growth Growth No Growth No Growth 0,2% + 0,2% No Growth Growth No Growth Growth No Growth No Growth 0,3% + 0,3% No Growth Slight Growth No Growth Slight Growth No Growth No Growth - Note
- Due to its transdermal properties, it is indicated that Glyceryl Monolaurate 90 % will improve the per-formance of the patch type delivery systems coming into vogue today. Further, Glyceryl Monolaurate 90 % should improve the penetration of lidocaine, capcaisin and similar actives used to relieve discomfort caused by teething, gum pain, cold sores and muscular aches.
Regulatory & Compliance