- Chemical Name:(2-Hydroxypropyl)-β-cyclodextrin
- Functions:Encapsulant, Stabilizer
- Certifications & Compliance:European Pharmacopeia (Ph. Eur.), GMP, Japan Pharmacopeia (JP), United States Pharmacopeia (USP)
- Labeling Claims:Pyrogen-free
- Synonyms:2-Hydroxypropyl-Beta-Cyclodextrin, beta-Cyclodextrin 2-Hydroxypropyl Ethers, HPBCD, HPbetaCD, HPCD, Hydroxypropyl Betadex, Hydroxypropyl-Beta-Cyclodextrin
KLEPTOSE® HPB Biopharma Hydroxypropyl Betadex Cyclodextrin is a low endotoxin grade materials that provides protein stabilization for biopharmaceutical downstream applications. With a hydrophobic internal cavity and hydrophilic exterior, KLEPTOSE® HPB BioPharma can encapsulate molecules, forming inclusion complexes where lipophilic compounds are non-covalently bound within the cavity. It is suitable for use in biopharmaceutical manufacturing and as an excipient for injectable dosage forms.
Benefits
Unique ability to encapsulate and shield water insoluble materials can be utilized to shield exposed hydrophobic residues on aggregation-prone proteins, thereby modulating protein aggregation
Shows promise as a multifunctional excipient suitable for biopharma applications
Can serve as a tool to synergistically complement biotherapeutic formulations
Multicompendial material (EP, USP, JP)
Features
Starch derivative
Cyclic oligosaccharide with a bucket-like structure
