L-HPC

Shin-Etsu Pharma, Nutra and Food Brand

Supplier:Shin-Etsu Pharma, Nutra and Food

Products:9

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP)

This dual functioning excipient acts as both a disintegrant and binder.
It is not the same as HPC.
L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.

L-HPC benefits are:

Enhanced stability because it is non-ionic and has low water activity
It is peroxide free and provides excellent compatibility for oxygen sensitive APIs
Improved disintegration

A variety of grades are available depending on the application.

View All L-HPC Products

L-HPC LH-B1

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Functions:Dispersant, Disintegrant
Dosage Form:Tablets, Pellets
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-B1 is suitable for fluidized-bed granulation, direct compression for high-load formulations and as a dispersion aid for capsules.

L-HPC NBD-020

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Functions:Dispersant, Binder
Dosage Form:Tablets, Pellets
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application.L-HPC NBD-020 is suitable for wet granulation.

L-HPC NBD-022

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Functions:Binder, Disintegrant
Dosage Form:Orally Disintegrating Tablets (ODTs), Tablets, Pellets
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application. L-HPC NBD-022 is suitable for direct compression and ODTs.

L-HPC LH-21

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Manufacturing Technology:Tablet Coating, Wet Granulation, Direct Compression
Functions:Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC LH-22

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Manufacturing Technology:Tablet Coating, Wet Granulation, Direct Compression
Functions:Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC LH-31

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Manufacturing Technology:Tablet Coating, Wet Granulation, Direct Compression
Functions:Disintegrant, Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-31 is suitable for wet granulation, pellet extrusion and layering.

L-HPC LH-11

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Functions:Dispersant, Disintegrant, Binder
Dosage Form:Tablets, Capsules, Pellets
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-11 is suitable for direct compression and prevents capping during compression.

L-HPC LH-32

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Manufacturing Technology:Tablet Coating, Wet Granulation, Direct Compression
Functions:Disintegrant, Binder
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-32 is suitable for wet granulation, pellet extrusion and layering.

L-HPC NBD-021

Chemical Name:Low-Substituted Hydroxypropyl Cellulose
Functions:Disintegrant, Binder
Dosage Form:Tablets, Pellets
Labeling Claims:Non-GMO, TSE-free, Allergen-free, Kosher, Solvent-free, BSE-free
Certifications & Compliance:National Formulary (NF), United States Pharmacopeia (USP), DMF Type IV, European Pharmacopeia (Ph. Eur.), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA), GMP, Japan Pharmacopeia (JP), Kosher

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application.L-HPC NBD-021 is suitable for direct compression and wet granulation.

Knowde Brand Summary

Identification

Chemical Name: Low-Substituted Hydroxypropyl Cellulose
Technologies: Pharmaceuticals & Nutraceuticals
Product Families: Excipients
Binders & Disintegrants,
Formulation & Processing Aids
Pharma & Nutraceuticals Functions: Binder,
Disintegrant,
Dispersant

Features & Benefits

Labeling Claims: Allergen-free,
BSE-free,
Kosher,
Non-GMO,
Solvent-free,
TSE-free

Applications & Uses

Markets: Healthcare & Pharma
Applications: Drug Delivery & Care Solutions
Oral
Pharmaceutical Manufacturing
Excipients & Coatings
Dosage Form: Capsules,
Orally Disintegrating Tablets (ODTs),
Pellets,
Tablets
Manufacturing Technology: Capsule Filling,
Direct Compression,
Tablet Coating,
Wet Granulation

Knowde Brand Highlights

Key Benefits of L-HPC: Higher stability due to its non-ionic nature and low water activity

No peroxide offers superior stability

Disintegration into smaller particles leading to better dissolution

Anti-capping effect for tableting process

Suitable for pellet extrusion as well as tableting

A variety of grades are available depending on application
Brand Highlights: Water insoluble, swells in water and works as dual functional ingredients,
disintegrant and binder for tablets and pellets.

Suitable grade can be selected depending on process and API characteristics.

Non-ionic polymer which has less interaction with API and better stability.