Products in Pharmaceutical Manufacturing: Tablets

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application.L-HPC NBD-021 is suitable for direct compression and wet granulation.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-B1 is suitable for fluidized-bed granulation, direct compression for high-load formulations and as a dispersion aid for capsules.

Amorphous solid dispersion is a technology for solubility enhancement of drugs.Shin-Etsu AQOAT® AS-MMP is used as solubility enhancement of poorly soluble APIs.

TYLOPUR® 65SH-4000is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 65SH-4000 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

Shin-Etsu AQOAT® AS-HF-Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media. It is also used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-MF -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

HPMCP is a monophthalic acid ester of hypromellose.HP-55S is enteric coating agent with greater strength and higher acid resistance due to its high molecular weight

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-21 is suitable for wet granulation.

TYLOPUR® 65SH-50 is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 65SH-50 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-31 is suitable for wet granulation, pellet extrusion and layering.

Amorphous solid dispersion is a technology for solubility enhancement of drugs.Shin-Etsu AQOAT® AS-LMP is used as solubility enhancement of poorly soluble APIs.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-32 is suitable for wet granulation, pellet extrusion and layering.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application. L-HPC NBD-022 is suitable for direct compression and ODTs.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-11 is suitable for direct compression and prevents capping during compression.

HPMCP is a monophthalic acid ester of hypromellose.HP-50 is enteric coating agent soluble at lower pH

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-22 is suitable for direct compression.

Shin-Etsu AQOAT® AS-LG -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application.L-HPC NBD-020 is suitable for wet granulation.

Shin-Etsu AQOAT® AS-HG-Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

TYLOPUR® 65SH-400 is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 65SH-400 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

Amorphous solid dispersion is a technology for solubility enhancement of drugs. Shin-Etsu AQOAT® AS-HMP is used as solubility enhancement of poorly soluble APIs.

TYLOPUR® 90SH-4 is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.TYLOPUR® 90SH-4 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

HPMCP is a monophthalic acid ester of hypromellose.HP-55 is a regular grade enteric coating agent.

Shin-Etsu AQOAT® AS-MG -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

AquaPolish® HS is a combination of film-forming polymer METHOCEL™ Premium VLV with plasticizing and coloring additives. The very low viscosity of HPMC enables high solid content dispersions for high speed productivity.

CompactCel® FLO is a flow agent for loosening powder mixtures and improving flowability. The ready-touse powder compound replaces synthetic additives such as silicon dioxide. It prevents bridge formation during flow from hopper and provides a clean funnel flow of the powder mass to be processed during both tableting and capsule filling.

BIOGRUND provides a wide range of ready-to-use film coating products which includes AquaPolish® MS. It's a moisture sealing product. It provides a protective and fast soluble film on tablets, pellets, granules and capsules. It is a combination of selected film-forming cellulose ethers with plasticizing and coloring additives. The use of hydrophobic excipients gives excellent protection against moisture. The product is designed to improve the coating process and can be applied using conventional or modern coating equipment. It is a homogeneous, dry-milled, powdered compound, developed for the coating of all kinds of solid dosage forms. It is easily soluble and a reproducible high-quality film coating can be achieved. Clear, white and colored preparations can be tailor-made according to customer requirements. Contact us for more information.

BIOGRUND’s ready-to-use coloring agent TopMill® provides a homogeneous solid-color product. It is a unique, dry milled, homogeneous and deagglomerated blend of colors with additional excipients.

The ingredient premix CompactCel® MAB provides an oil and moisture holding capacity and prevents clumping of your powder blend. The homogeneous dry powder product controls humidity related issues in formulas or absorbs oily substances into free flowing powder.

AquaPolish G has been developed for the coating of all kinds of solid dosage forms. It is easily soluble and a reproducible high-quality film coating can be guaranteed. The widely approved, mineral colors of Candurin® are based on natural silicate combined with titanium dioxide and/or iron oxide.

AquaPolish® STA has been developed for the fast coating of oral solid dosage forms. It is easily soluble and a reproducible high-quality film coating can be guaranteed. Due to its high solid content of 20–25% in the dispersion, a fast application at low process temperatures will improve your production process and save time. Additionally, your product gains a small barrier against moisture.

BIOGRUND’s ready-to-use sugarcoating system IsuPolish® G is a unique, dry milled, homogeneous blend of isomalt mixed with mineral, non-artificial Candurin® pearl effect colors and additional excipients. The use leads to lustrous effects on sugar-coated tablets, granules, chewing gums, nuts and fruits. It also offers sophisticated solutions for brand enhancement and product refinement.

BIOGRUND’s one-step binding agent CompactCel® provides an easy to use, granulated and homogeneous compound of PVP/NaCMC or HPC/ NaCMC, which acts as a perfect dry binder.

AquaPolish® SR creates a strong and insoluble film coating with good adhesion, through which the active ingredient diffuses. The use of highquality, insoluble cellulose ethers or Ammonio Methacrylate Copolymer (Type A, Type B) in combination with soluble cellulose ethers, plasticizing and coloring additives, guarantees film coatings that are always reproducible. By varying the type and amount of the cellulose ethers used, a wide range of release profiles can be achieved.

AquaPolish® TC is a combination of HPMC, HPC and other cellulose ethers with taste masking additives. Due to the further additives, which form a hardly soluble film, a tastemasking is achieved.

BIOGRUND’s one-step tabletting agent CompactCel® SIL provides an easy to use, granulated and homogeneous compound of Silica and PVP/ NaCMC or HPC/NaCMC, which acts as a perfect dry binder granulate.