Knowde Enhanced TDS
Identification & Functionality
- INCI Name
- Cosmetic Ingredients Functions
- CAS No.
- 55406-53-6
- EC No.
- 259-627-5
- Technologies
- Product Families
- Compositional Breakdown
Chemical Compound Breakdown Cas No. EINECS No. 3-Iodo-2-propynylbutylcarbamate 55406-53-6 259-627-5 Cyclodextrin derivative N/A N/A Water 7732-18-5 231-791-2 Chemical Compound Breakdown % 3-Iodo-2-propynylbutylcarbamate 5.5-6.5% Cyclodextrin derivative 46-48% Water 46-48%
Features & Benefits
- Benefit Claims
- Labeling Claims
- Key Attributes
- Highly effective fungicide; remarkably efficient in inhibiting
growth of yeast and mold - Has a wide range of global regulatory approval
- Broad pH applicability
- Water-soluble
- Temperature stable
- Compatible with commonly used ingredients such as cationic, anionic, nonionic surfactants, emulsifiers and proteins
- Convenient form provides easier handling
- Low use levels for efficac
- Highly effective fungicide; remarkably efficient in inhibiting
Applications & Uses
- Markets
- Applications
- Bath & Shower Applications
- Color Cosmetic Applications
- Hair Care Applications
- Personal Hygiene Applications
- Skin Care Applications
- Wipes, Tissue & Towel Applications
- Use Level
- 0.15-0.5%
- Application pH Range
- 2–9
- Applications
- Anhydrous
- Baby care (rinse-off only)
- Body wash
- Conditioner
- Cream
- Deo/ Anti-perspirant
- Eye creams/gels
- Eye shadow
- Face lotion
- Face wipes
- Facial cream
- Foundation
- Hair gel
- Hand soap
- Lotion
- Make up remover
- Mascara
- Oil in Water
- Powder
- Shampoo
- Toner
- Water in Oil
- Formulation Recommendations
- Soluble in water up to 95% allowing for wider formulation flexibility
- Fully compatible with a wide variety of formulations as well as all types of cationic, nonionic and anionic systems
- Can be added virtually anywhere in the manufacturing process
- Can be added at both room and elevated temperatures as high as 50°C for as long as 6 hours without loss of efficacy
- Wide pH range: 2–10
- Can be inactivated by strong reducing agents, acids and bases
- Typically needs to be used in combination with a bactericide
- DMDMH (Glydant® products), phenoxyethanol, CMI/MI (Isocil® products) or other bactericide can be used
- Formulator to confirm that there are no patent issues
- Glycacil® 2000 is freeze/thaw/heat stable without phase separation or crystal formation through several cycles
- Glycacil® 2000 shows significant improvement in both activity retention and resistance to color development versus
- solvent-based IPBC products (see below)
- Formulation Recommendations: activity retention and resistance to color development versus solvent-based IPBC products
%IPBC APHA color Glycacil® 2000 Solvent-based product Glycacil® 2000 Solvent-based product Initial 6.4 9.1 115 794 Room Temperature 1 month 6.3 9 125 901 3 months 6.0 8.8 146 936 6 months 6.4 8.9 210 1024 50˚C 1 month 6.3 7.8 1276 1386 Sunlight 1 week 6.2 9.1 339 1093 2 weeks 6.4 9.1 339 1094 1 month 6.2 8.8 383 1094 3 months 5.9 8.5 833 1114
Properties
- Physical Form
- Soluble in
- Oil
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Global Regulatory
Europe
- Approved under Annex V to Regulation EC/1223/2009
- Allowed in rinse-off products up to 0.02% IPBC and up to 0.01% IPBC in leave-on products except in creams and lotions aimed to be applied on a large part of the body
- Allowed for use in antiperspirants/deodorants up to 0.0075% IPBC
- Not allowed for oral hygiene and lip products or in preparations for children under the age of 3 except in rinse-off applications
Japan
- Listed in the positive list. Can be used at a level up to 0.02% IPBC in leave-on and rinse-off products
United States
- Approved by CTFA for both rinse-off and leave-on applications.
Maximum use level of 0.1% for IPBC
Technical Details & Test Data
- Efficacy
Microbiological Challenge Studies Studies were run using various concentrations of Glycacil® 2000 in various formulations to see efficacy on a mixed inoculum of fungi. All samples were inoculated at the beginning of the study, sampled at 24 hours, 3, 7, 14, 21 and 28 days.
- Efficacy of Shampoo Formula
Ingredient % wt/wt Sodium lauryl ether sulfate 35.0% Triethanolamine lauryl sulfate 25.0% Cocamide DEA 3.0% Anhydrous protein 3.0% Sterile DI water 36.0% Total 100.0% Efficacy in the shampoo formulation Organism count (cfu/ml) / Contact time (days) Test Organisms 0 7 14 21 28 Mix Fungi Glycacil® 2000 0.078% 1.4x10^5 <10 <10 <10 <10 Glycacil® 2000 0.04% 1.2x10^5 <10 <10 40 <10 Glycacil® 2000 0.016% 1.6x10^5 2.5x10^3 1.2x10^3 4.5x10^3 4.0x10^2 - Efficacy of Cream Formula
Ingredient % wt/wt Glyceryl monostearate 6.0% POE 20 glyceryl monostearate 4.0% Cetearyl alcohol 1.5% Myristyl propionate 8.0% Glycerin 5.0% Sterile DI water 75.5% Total 100.0% Efficacy in the cream formulation Organism count (cfu/ml) / Contact time (days) Test Organisms 0 7 14 21 28 Mix Fungi Glycacil® 2000 0.468% 1.8x10^5 50 20 10 <10 Glycacil® 2000 0.312% 2.6x10^5 6.0x10^2 1.3x10^2 40< 10 Glycacil® 2000 0.156% 3.0x10^5 4.0x10^3 2.0x10^3 1.3x10^3 1.4x10^3 - Comparative Fungicidal Activity of Glycacil® 2000 to Parabens
The focused fungicidal activity of the IPBC in Glycacil® 2000 leads to greater efficacy and lower usage levels versus competitive chemistries.
- Mix fungi: A.niger ATCC#16404 + C.albicans ATCC#10231
% of preservative (as supplied) required to achieve < 10 cfu/ml. of the mix fungi in anionic shampoo
Day 7 Day 14 Day 21 Day 28 Glycacil® 2000 < 0.04 < 0.04 < 0.04 < 0.04 Parabens 2:1 ratio Methyl: Propyl > 0.6 > 0.6 > 0.6 > 0.6
Packaging & Availability
- Country Availability
- Regional Availability