Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
- Origin
Marine-derived ferment of Sargassum vulgare. Rich in bioactive phlorotannins that rejuvenate and protect through the stimulation of the skin's natural DNA repair processes.
Features & Benefits
- Benefit Claims
- Labeling Claims
- Benefits & Claims
- Marine-derived active produced from Sargassum vulgare via a proprietary fermentation process
- Rich in bioactive phlorotannins
- Stimulates repair of UV-damaged DNA in vitro and ex vivo
- Provides strong antioxidant protection
- Inhibits COX-2 activity for inflammatory protection
- Inhibits the inflammatory effects of urban air pollution
- Modulates expression of 21 genes important for healthy skin at the molecular level
Applications & Uses
- Markets
- Color Cosmetic Applications
- Skin Care Applications
- Sun Care Applications
- Use Level
- 0.5 - 2%
- Applications
- De-stressing anti-aging regimes to enhance natural skin repair
- Anti-aging regimes targeting oxidative and inflammatory damage (caused by pollution, UV radiation, etc.)
- Day creams and pre- and post-sun products
- Soothing and calming products for sensitive skin
- Emulsions, creams, and lotions
- BB creams, CC creams, and color formulations
- Compatibility and Formulation
- DermalRx® FSE is water miscible and compatible with most conventional ingredients used in skincare products. Add in the last step of formulation when temperature is below 50°C. Finished formulas containing DermalRx® FSE should be protected from prolonged exposure to direct light, as this may cause the product to darken slightly.
Properties
- Physical Form
Regulatory & Compliance
- Certifications & Compliance
- Regulatory Information
- This product has not been tested on animals, and our company adheres to the written provisions of such animal rights organizations as Leaping Bunny and Cruelty/Free International.
- This product contains no animal products. It is manufactured using only plant based or synthetically derived (non-animal origin) materials and is thereby declared a Vegan Product.
- All materials used to produce this product are procured using sustainable sourcing practices.
- This product is manufactured in accordance with the current Good Manufacturing Practices (cGMP) requirements established by the U.S. Food and Drug Administration (FDA) for cosmetics. Furthermore, Biocogent, LLC, and this production facility(ies), are registered as cosmetic manufactures with the FDA.
- REACH compliance: All of the ingredients (substances) used in the manufacture of this product (mixture)are either registered under REACH, or qualify for an Article 2 (low volume of less than 1 metric ton), Annex IV or Annex V exemption, making our product REACH compliant.
- Proposition 65 compliance: Based upon Biocogent LLC’s knowledge of our business operations and chemical formulations, no chemicals listed by the State of California Environmental Protection Agency are used in our products, or as a processing aid for any product manufactured in our facility.
Technical Details & Test Data
- Test Data
DermalRx® FSE Stimulates DNA Repair
The gross tissue morphology of the skin was well preserved by DermalRx® FSE treatment as observed post-UV exposure.
DermalRx® FSE stimulates tissue repair and completely eliminates CPD lesions within 24 hours of UV exposure of human skin explants.
Tissues treated with DermalRx® FSE had 97% less DNA damage than untreated tissues 24 hours after UV exposure.
Safety & Health
- Safety
- Human Repeat Insult Patch Testing (HRIPT) under semi-occlusive conditions indicated that DermalRx® FSE is not a primary skin irritant or a primary skin sensitizer when tested neat. DermalRx® FSE tested as non-phototoxic at recommended use levels. Occular testing ranks full strength DermalRx® FSE as a non-irritating, minimal ocular irritant. The iodine level in DermalRx® FSE is ≤10ppm.
Storage & Handling
- Shelf Life
- 15 Months
- Storage Condition
- DermalRx® FSE should be stored at RT (18-25°C) in original packaging away from heat and light. Product may darken upon long-term storage.