Knowde Enhanced TDS
Identification & Functionality
- Carrier
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
- Origin
- Grandiciin® is a plant-dervied active produced from Epimedium sagittatum, rich in a beneficial mix of prenylated flavonoids including icariin and epimedins
Features & Benefits
- Benefit Claims
- Labeling Claims
- Benefits & Claims
- Plant-derived active produced from Epimedium sagittatum
- Contains beneficial flavonoids and flavonoid derivatives including icariin and epimedins
- Helps to reduce biofilm-resident C. acnes, which is particularly abundant in blemished skin
- Inhibits production of inflammatory mediators: MIP-1β, MCP-1, IL-1β, IL-6, IL-8, GM-CSF
- Modulates pro-inflammatory PLA2 and COX-2 activities
- Protects the extracellular matrix via inhibition of proteolytic stress
- Protects against oxidative damage due to inflammation and environmental stress
- Modulates the expression of 11 genes to improve skin’s appearance Clinical trial results showed:
- 25% reduction in sebum in just two weeks
- 36% reduction of C. acnes-associated coproporphyrin III
- Significant improvement of blemishes and redness
Applications & Uses
- Markets
- Skin Care Applications
- Treatment Product Applications
- Use Level
- 0.5 - 2.5%
- Applications
- Skin health and wellness to maintain skin homeostasis through microbiome-rebalancing
- Formulas to address mild-to-moderate blemishes in young and adult consumers
- Clay masks and other skin care products targeting consumers with oily skin
- Soothing and calming products for damaged skin
- Body care products
- Spot treatments
- Compatibility and Formulation
- Grandiciin® is compatible with most conventional ingredients used in skincare products. It is miscible in aqueous and glycolic systems. Add in the last step of formulation when temperature is below 50°C. Mix well before use.
Properties
- Physical Form
Regulatory & Compliance
- Certifications & Compliance
- Regulatory Information
- This product has not been tested on animals, and our company adheres to the written provisions of such animal rights organizations as Leaping Bunny and Cruelty/Free International.
- This product contains no animal products. It is manufactured using only plant based or synthetically derived (non-animal origin) materials and is thereby declared a Vegan Product.
- All materials used to produce this product are procured using sustainable sourcing practices.
- This product is manufactured in accordance with the current Good Manufacturing Practices (cGMP) requirements established by the U.S. Food and Drug Administration (FDA) for cosmetics. Furthermore, Biocogent, LLC, and this production facility(ies), are registered as cosmetic manufactures with the FDA.
- REACH compliance: All of the ingredients (substances) used in the manufacture of this product (mixture)are either registered under REACH, or qualify for an Article 2 (low volume of less than 1 metric ton), Annex IV or Annex V exemption, making our product REACH compliant.
- Proposition 65 compliance: Based upon Biocogent LLC’s knowledge of our business operations and chemical formulations, no chemicals listed by the State of California Environmental Protection Agency are used in our products, or as a processing aid for any product manufactured in our facility.
Technical Details & Test Data
- Test Data
Reduction of C. Acnes Burden & Associated Blemishes
Grandiciin reduces burden on the skin (red fluorescence) while C. acnes also remarkably diminishing the appearance of blemishes, redness, and other signs of inflammation after four weeks of twice-daily application.
Grandiciin® Reduction of C. Acnes Biofilm
Over 1200x reduction of problematic biofilm-resident C. acnes with the application of 1.25% Grandiciin®.
Safety & Health
- Safety
- Human Repeat Insult Patch Testing (HRIPT) under semi-occlusive conditions indicated that Grandiciin®, when tested neat, is not a primary skin irritant or a primary skin sensitizer. EpiOcular(TM) irritancy testing predicted that Grandiciin® would be a Minimal ocular irritant when tested neat and at recommended use levels.
Storage & Handling
- Shelf Life
- 18 Months
- Storage Condition
- Grandiciin® should be stored at room temperature in original packaging. Protect from extended cold storage and freezing.