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G-Hexuron™

G-Hexuron is the stabilized form of Vitamin C that can be topically applied to the skin in advanced formulations specifically targeted for anti-aging and photo-protection benefits. G-Hexuron is the water soluble, Vitamin C, 2-derivative with superior formulation stability. G-Hexuron is both bioavailable and bioactive in its 2-glucoside form and has been shown to be more bio-persistent over time vs. Vitamin C. G-Hexuron is photo-protective, visibly lightens skin and possesses anti-aging properties similar to Vitamin C.

INCI Name: Ascorbyl Glucoside

Vitamin Type: Vitamin C

Ingredient Origin: Biotechnology

Labeling Claims: 1,4-Dioxane-free, BSE-free, Bisphenol A-free, Butylated Hydroxyanisole-free, Butylated Hydroxytoluene (BHT)-Free, CMR Substances-free, Clean at Sephora, Credo Clean Standard, Formaldehyde-free, Fragrance allergen-free, GMO-free, Gluten-free, Glycol ether-free, Hormones-free, Latex-free, Nanomaterials-free, Nitrosamines-free, Non-Phenolic, Not Listed In California Proposition 65, Not Tested on Animals, Palm Oil-free, Palm free, Paraben-free, Petrochemical-free, Phthalates-free, SVHC Chemicals-free, Silicone-free, Soy-free, Sulfate-free, TSE-free, Talc-free, Ulta Beauty's Conscious Beauty, VOC-free

Benefit Claims: Age & Dark Spot Reduction, Anti-Aging, Anti-Inflammatory, Anti-Wrinkle, Antioxidant Properties, Collagen Boosting, Photo-Aging Protection, Skin Lightening, Skin Whitening, Whitening

Synonyms: 2-O-alpha-D-glucopyranosyl-L-ascorbic acid, AA-2G, L-Ascorbic Acid 2-Glucoside

Knowde Enhanced TDS

Identification & Functionality

Chemical Name
Country of Origin
Ingredient Origin
Vitamin Type
CAS No.
129499-78-1
EC No.
425-980-0

Features & Benefits

Applications & Uses

Color Cosmetic Applications
Hair Care Applications
Use Level
1 - 2 %

Properties

Physical Form
Appearance
White to cream powder
Soluble in
Water
Typical Properties
ValueUnitsTest Method / Conditions
pHapprox. 2 - 2.5
Melting Pointapprox. 158 - 163°C
Optical Rotationapprox. 186.0 - 188.0Degree
Loss on Dryingmax. 1.0%
Residue on Ignitionmax. 0.2%
Free Ascorbic Acid Contentmax. 0.1%
Free Glucose Contentmax. 0.1%
Heavy Metals Content (as Pb)max. 10ppm
Arsenic Content (As₂O₃)max. 1ppm
Assaymin. 98%
Composition
ValueUnitsTest Method / Conditions
Ascorbyl Glucoside Content100%
Residual Solvents
ValueUnitsTest Method / Conditions
Ethanol Contentmax. 1000ppm

Regulatory & Compliance

Technical Details & Test Data

In-Vivo Testing of G-Hexuron™ to Show Skin Lightening Effect
  • In clinical testing, sixteen female volunteers, ages (37 to 55) were used to test the skin lightening effects.
  • 2% G-Hexuron™ was applied twice a day for a period of 90 days to show an increase in skin lightening.

G-Hexuron™ - In-Vivo Testing of G-Hexuron To Show Skin Lightening Effect

  • As a result, skin lightening increased by 80% in 45 days, and 120% in 90 days. Which is a ratio of 1.5 on day 45, and 2.5 after 90 days.
In-Vivo Testing of G-Hexuron™ to Show Anti-Wrinkle Effect
  • Clinical testing in an anti-aging skin study was conducted on six-teen female volunteers, age 37 to 55.
  • 2% G-Hexuron™ in a formulation was applied twice a day over 90 days. The formulation was applied to the lateral area (crow’s feet area) of the volunteers eyes and thoroughly across the cheek area.

G-Hexuron™ - In-Vivo Testing of G-Hexuron To Show Anti-Wrinkle Effect

  • As a result, the appearance of wrinkle depth is well improved after 45 days and substantially improved at 90 days.
In-Vitro Testing of G-Hexuron™ to Show Melanin Reduction

An in-vitro culture was treated with 2 mmol/L of G-Hexuron™, AA-2P, or Vitamin C (Vit. C). Melanin content was checked after 24 and 48 hours.

G-Hexuron™ - In-Vitro Testing of G-Hexuron To Show Melanin Reduction

After one day, G-Hexuron™ significantly reduced melanin content compared to untreated cells. After two days, G-Hexuron™ significantly reduced melanin content compared to all other groups.

In-Vitro Testing of G-Hexuron™ to Show it Promotes Collagen Protein Synthesis
  • An in-vitro culture of human fibroblasts was grown in the presence of 0.25 mM Vitamin C (Vit. C), AA-2P or G-Hexuron for 1-8 days.
  • G-Hexuron™ promoted a significant increase in collagen synthesis compared to the untreated group.

G-Hexuron™ - In-Vitro Testing of G-Hexuron To Show It Promotes Collagen Protein Synthesis

  • Notably, collagen synthesis decreased in Vitamin C and AA-2P treated cells at day 5, while levels for G-Hexuron treated cells remained stable.

Storage & Handling

Shelf Life
2 years
Storage Conditions

Store in a cool, dry and well-ventilated area in a tightly closed container.