Brands in Binders & Disintegrants

Adi-pure® high-purity adipic acid (hexanedioic acid) is a crystalline, white powder that exhibits typical carboxylic acid chemistry suitable for a wide variety of applications. The high purity, excellent uniformity, and consistent end-use performance of Adi-pure® makes it a valuable intermediate in a wide range of applications.

Kollidon® grades are processed via melt granulation, spray drying, and HME, these materials are suitable for a variety of formulations. Whether the target formulation is a tablet or transdermal patch, the Kollidon® family of multifunctional excipients is ready to resolve any formulation challenge. Kollidon® excipients come in various grades, giving you the flexibility to tailor your formulation based on your individual needs.

TYLOPUR® is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations. In addition, TYLOPUR® is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

Kollicoat® polymers can also be used for taste masking to improve patient compliance. While these excipients are predominantly used for oral applications, coating polymers can also be utilized for the development of topical films and transdermal patches as film and matrix formers, respectively. The Kollicoat® family of coating polymers consists of a broad range of chemistries to address various film coating challenges.

Shin-Etsu Chemical Co., Ltd. began to produce water soluble cellulose ethers in 1962, with the trade name METOLOSE®. METOLOSE® consists of Methylcellulose (methylcellulose USP) and three substitution types of Hydroxypropylmethylcellulose (Hypromellose USP) each available in several grades differing in viscosity. METOLOSE® can be used as a binder for solid dosage forms such as tablets and granules. It also provides a variety of functions such as water retention, thickening, protective colloid, surface activity, etc. It also can be used as a hydrophilic matrix agent. The hydrophilic matrix system is the simplest sustained release technology for oral dosage forms, consisting essentially of a drug and a water soluble highly viscous polymer. Recent advances in this hydrophilic matrix system have allowed more controllable and reproducible drug release by controlling the chemical and physical properties of the polymer. METOLOSE® SR is especially suitable for this application, and provides a genuine consistency in the final products.

TYLOPUR Xtend Nutra® is a plant derived ingredient (high viscous hydroxypropyl methylcellulose, HPMC) that has been developed by Shin-Etsu to provide a controlled, extended release of active compounds over a longer period of time, prolonging their effects on human body. TYLOPUR Xtend Nutra® acts as a hydrophilic matrix agent in hydrophilic matrix system, which is the simplest sustained release technology, consisting essentially of an active compound and a water soluble highly viscous natural polymer. Such a system allows a simple and straight forward direct compression formulation and a reduction of doses per day. It is not only cost effective but it is also consumer friendly. The mechanism of action of TYLOPUR Xtend Nutra® in hydrophilic matrix tablets consists of initial swelling caused by the hydration of a tablet, protective gel formation, which regulates the degree of active compound’s release, and time-related extended release of an active compound through the gel layer.

Combination of two or more compendial or non-compendial excipients designed to physically modify their properties without chemical change not leading to the formation of covalent bonds. The combination and selction of ingredients is designed to maximize performance their functionality.

Inter-Continental Oils & Fats (ICOF), a member of Musim Mas Group, serves vegetable refined Glycerine of various grades and feed-stocks backed by our Asian oleochemical production facilities as well as our European refinery Dutch Glycerin Refinery B.V. (DGR) located within Delfzijl Chemical Park providing easy logistical access to major European, Middle East, African and American end markets via road, rail, barge and sea. The material can be packed in drums or IBC as per request.

Kollitab™ DC 87 L is an almost white, odorless, and free-flowing powder. It is a coprocessed excipient based on lactose monohydrate (87%), crospovidone (9%), Kollicoat® IR (3%) and sodium stearyl fumarate (1%).

CAPMUL® multi-functional, high purity monoesters provide superior skin penetration and emolliency with excellent effects against microorganisms. Certain grades of CAPMUL® may be used to inhibit the growth of gram positive and negative bacteria, yeast, and mold in many "preservative free" products. They are used to produce stable emulsions, to modify viscosity and they can act as carriers and vehicles in selected applications.

TYLOPUR ClearCoat Nutra® is a plant derived, water soluble ingredient (low viscous hydroxypropyl methylcellulose, HPMC) that has been developed by Shin-Etsu as a natural and easy-to-use material for film coating of nutraceutical and nutritional supplement tablets. It can be quickly dissolved in water at room temperature and does not require any additional ingredients for a successful coating. TYLOPUR ClearCoat Nutra® provides an excellent finish, that can protect tablets from humidity and reduces their overall friability during packaging. Moreover, coating with TYLOPUR ClearCoat Nutra® can improve the mouth feel and swallowability for consumers. Additionally, TYLOPUR ClearCoat Nutra® is recommended for wet granulation to improve particle size, powder flow and compressibility of nutraceutical actives.

SOLUTAB® Croscarmellose sodium is a superdisintegrant that provides an efficient disintegration at low level of use. Disintegration performance is obtained through the wicking and swelling capacity of SOLUTAB® that can be maximized via the selection of its origin (wood or cotton). Three grades are available to help you optimize your product selection. It is flexible as it is adapted to wet and dry granulation or direct compression processes. SOLUTAB® is a crosslinked carboxymethyl cellulose sodium. SOLUTAB® can be used in various oral dosage forms in both pharmaceutical and nutraceutical applications as an excipient including swallowable tablets, orally dispersible tablets, hard capsules, blends, granules and pellets premix.

SweetPearl® maltitol powder is a versatile polyol, a tooth friendly sugar substitute. It is a sugar alcohol similar to Xylitol and Sorbitol.   Benefits: + Lower glycemic index than sugar + Does not cause tooth decay + Fewer calories than sugar gram for gram + Safe sugar substitute   Maltitol is a substitute for Sucrose and is derived from corn.   Commonly used as a sweetener in: + Desserts + Gum + Mouthwash + Vitamins and other potentially bitter foods and supplements + Dairy + Diabetic products + Other candy, confections and sweetened foods

NEOSORB® are sugar-free, low caloric bulk sweeteners providing a variety of functional properties in confectionery and seafood products, offering a wide range of textures for tooth-friendly chewing-gums contributing to oral health. Dental plaque, a sticky bacterial film that develops on dental enamel, reoccurs after every meal. Those microorganisms feed on sugar fermentation, produced by destructive acids attacking the teeth's enamel. NEOSORB® sorbitol powder does not produce acids or cause tooth decay as they are not metabolized by the oral bacteria.

CLEARGUM® are thin-boiling or octenyl succinate starches

LYCATAB® DSH is a high-performance wet granulation binder for swallowable tablets with low impact on dissolution. It is a natural origin binder developed specifically for wet granulation. It is completely soluble in cold water and has excellent wettability. These characteristics make it a versatile excipient whatever the granulation equipment you have available (high shear, fluid bed, twin screew) and whatever the incorporation of your binder (in the dry mix or as a binding solution). The low viscosity benefit to a short granulation process and a low impact of the binder on the disintegration and dissolution profile of your formulation.

XYLISORB® Xylitol sugar-free sweetener with a high cooling effect.

GLYCOLYS® Sodium starch glycolate provides pharmaceutical and nutraceutical manufacturers with a range of super-disintegrants for different formulation needs. Our GLYCOLYS® product provides this benefit for swallowable tablets, orally dispersible tablets and hard capsules. Roquette has been producing sodium starch glycolate for more than 20 years. We have developed different grades of GLYCOLYS® to meet specific needs, such as withstanding high shear granulation, acidic conditions or with a low organic solvent content.

MICROCEL® is the pure form of Microcrystalline Cellulose, serving as insoluble fiber, extrusion auxiliary, anti-caking and compression agent. It’s a physiologically inert, safe, sugar and gluten-free. Microcrystalline Cellulose is obtained through acid hydrolysis of cellulose, a substance naturally present in plants, fruits, and vegetables. Roquette sells these products under the MICROCEL® brand. MICRCOCEL® is a 100% insoluble fiber, physiologically inert, safe, sugar and gluten-free. Roquette’s team of experts – backed by its application lab and pilot equipment – is always ready to help you make the most of the benefits you are looking for in your development project or to help you meet your product optimization targets. Contact us to discuss your needs!

PEARLITOL® Flash Co-processed mannitol starch provides excipient functional properties of filler/binder as well as some disintegrant benefit to your orally dispersable tablets. PEARLITOL® Flash offers excellent chemical inertness, consistent rapid disintegration whatever the compression force making tablet formulation surprisingly simple. It is a compound of mannitol and starch adapted to direct compression formulation. PEARLITOL® Flash can be used in various oral dosage forms in both pharmaceutical and nutraceutical applications including fast disintegrating tablets and orally dispersible tablets.

XYLISORB® Xylitol powders can be used to provide excipient benefits including coatings, filler and filler/binder while providing nutrient benefits as a bulk sweetener. These benefits can be seen in various oral dosage forms in both pharmaceutical and nutraceutical applications including swallowable tablets and medicated confectionaries. Xylitol is a five-carbon polyol with a characteristic crystalline shape. XYLISORB® is particularly useful as a low calorie sugar-free ingredient that is known for its high natural sweetness. This makes it suitable to be used in formulation addressing all type of patient populations including pediatric and diabetic.

TACKIDEX® dextrins are derived from pea and potato to enhance crispiness and crunchiness of coatings. TACKIDEX® can also act as a carrier or encapsulant to encapsulated flavors and can also be used for glazing.

NEOSORB® XTAB are a range of tooth friendly and versatile powder sorbitol for creative sugar-free tablets. Directly compressible, it provides good flowability and productivity to your mints and tablet production. It can help deliver a smooth, hard and uniform colored surface as well as a clean, cooling effect. NEOSORB® XTAB sorbitol powder does not produce acids or cause tooth decay as they are not metabolized by oral bacteria. Additionally, European regulation recognizes the nutritional benefits of polyols (Maintenance of Tooth Mineralization, Toothfriendly generic EU claims).