Products in Pharmaceutical Manufacturing: Disintegrant

Galaxy™ 789 SP-MB, an anionic surfactant in needle form, minimizes dusting while boasting excellent foaming power, detergency, and emulsification capabilities. Trusted across industries, it finds application in toothpaste as a foaming agent and in pharmaceuticals as an emulsifier. With its multifunctional properties, Galaxy™ 789 SP-MB ensures optimal performance in various formulations.

Galaxy™ 799 SP-MB is a versatile anionic surfactant tailored for healthcare, personal care, and industrial applications. Its high foaming, emulsifying, and cleansing properties make it ideal for drug delivery, pharmaceutical manufacturing, and personal care products such as bath and shower essentials, hair care items, and oral care solutions. With its solid physical form and hard water tolerance, it enhances detergents and industrial cleaning agents. The RSPO massbalance certification underscores its commitment to sustainable resourcing. Whether used in pharmaceuticals or textile manufacturing, Galaxy™ 799 SP-MB ensures excellent performance and low dust formation.

Galaxy™ 799 (16) is a versatile anionic surfactant catering to various industries and applications. It serves in the healthcare and pharmaceutical sectors for oral and topical drug delivery, as well as in pharmaceutical manufacturing. In personal care, it enhances bath and shower products, hair care, and oral care formulations. With its high foaming, detergency, and emulsifying properties, it finds utility in home care, industrial cleaning, and surface care products. Whether in solid form for detergents or in gel for shower gels, Galaxy™ 799 (16) ensures optimal performance. Additionally, it features hard water tolerance and serves as a performance enhancer, making it an ideal choice for diverse formulations, including textile auxiliaries in manufacturing processes.

Galaxy™ 796 G-MB, an anionic surfactant in granular form, ensures rapid dissolution in water, minimizing dust compared to powder forms. Renowned for its exceptional foaming power and detergency, it finds application in toothpaste, shampoos, and detergent powder as a cleanser. Offering versatility and efficiency, Galaxy™ 796 G-MB is a reliable choice across various formulations.

Galaxy™ 689-MB is a versatile anionic surfactant renowned for its exceptional foaming power, detergency, and emulsifying capabilities. Thriving under alkaline conditions, it finds extensive use in home and personal care applications. Additionally, it serves as an emulsifier in pharmaceuticals, a scouring agent in textile auxiliaries, and an emulsifying agent in emulsion polymerization processes. With its multifaceted functionality, Galaxy™ 689-MB proves indispensable across various industries and formulations.

Galaxy™ 799 (16)-MB is a multifunctional anionic surfactant suited for various industries and applications. It finds utility in the healthcare and pharmaceutical sectors for oral and topical drug delivery, as well as in pharmaceutical manufacturing. In personal care, it enriches bath and shower products, hair care, and oral care formulations. With attributes such as high foaming, detergency, and emulsifying properties, it contributes to home care and industrial cleaning products, including surface care solutions. Whether in solid form for detergents or gel for shower gels, Galaxy™ 799 (16)-MB ensures optimal performance. Additionally, its RSPO MassBalance certification reflects its commitment to sustainability.

Galaxy™ 799-MB is a versatile anionic surfactant suitable for personal care and industrial cleaning applications. Its formulation excels in bath and shower products, hair care items, and oral care solutions due to its high foaming and cleansing properties. Ideal for detergent manufacturing, it ensures effective cleaning in both household and institutional settings. With its solid physical form and hard water tolerance, it enhances performance in industrial cleaning agents and textile manufacturing processes. Additionally, its RSPO massbalance certification underscores its commitment to sustainable resourcing. Galaxy™ 799-MB guarantees superior foaming, low dust formation, and excellent performance across various applications.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application.L-HPC NBD-021 is suitable for direct compression and wet granulation.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-B1 is suitable for fluidized-bed granulation, direct compression for high-load formulations and as a dispersion aid for capsules.

SmartEx® is a co-processed excipient which consists of L-HPC, D-mannitol and fully hydrolyzed polyvinyl alcohol (PVA) and it specially designed for orally disintegration tablets (ODTs) and also immediate release tablet formulation by direct compression. All the excipients are widely used in pharmaceutical industry. One of the main advantage over other co-processed excipients is that SmartEx® contains L-HPC and therefore gives excellent stability.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.NBD Grades:Better flowability because of the non-fibrous particle shapeBetter compressibilityBetter tasteEnhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsA variety of grades are available depending on the application. L-HPC NBD-022 is suitable for direct compression and ODTs.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-11 is suitable for direct compression and prevents capping during compression.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-32 is suitable for wet granulation, pellet extrusion and layering.

SmartEx® is a co-processed excipient which consists of L-HPC, D-mannitol and fully hydrolyzed polyvinyl alcohol (PVA) and it specially designed for orally disintegration tablets (ODTs) and also immediate release tablet formulation by direct compression. All the excipients are widely used in pharmaceutical industry. One of the main advantage over other co-processed excipients is that SmartEx® contains L-HPC and therefore gives excellent stability.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-31 is suitable for wet granulation, pellet extrusion and layering.

CompactCel® DIS is a natural/organic super-disintegrant which enables a rapid break-up of solid dosage forms when they come into contact with moisture. The super-disintegrant premix is formulated with natrual ingredients which complies with current Clean Label Standards. It provides an alternative to synthetic super-disintegrants, such as crosslinked polymers, crosscarmellose sodium or sodium starch glycolate. CompactCel® DIS helps in the fast breakdown of the solid dosage form so that the active ingredient becomes bioavailable faster and is readily absorbed. It can be also used in the formulation of oral disintegrating tablets (ODT) or chewing tablets.

DICOM SANAQ® LS 004 have average particle size of 300 - 550 microns. It is a combination of Lactose Monohydrate and Starch (maize). Lactose is water loving and soluble in water, at high compression force it hampers disintegration. Starch has multifunction characters and act as binder as well as disintegrant. Starlose has optimized composition of these two ingredients.

Jungbunzlauer Citric acid DC is a direct compressible type of citric acid coated with a thin layer of maltodextrin.

Golden-Shell Pharmaceutical CHITOSAN (MEDICAL GRADE) is a non-toxic and odorless.It is a off-white or slight yellow powder. Soluble in acid,and insoluble in water,base or normal organic solutions.

Huangshan Bonsun Pharmaceuticals Crospovidone Food grade E1202 is a white or almost white free-flowing powder, no special odor, insoluble in water, acid, alkali and common solvents; it has strong swelling in water, does not form a gel after swelling, and has very good compatibility with polyphenols. , Carboxylic acid, tannin and small molecule substances complex. It is considered to be the preferred disintegrant for high-end tablets. It is especially suitable for the formulation of instant and chewable tablets. It is also widely used in food-grade products and beer and beverage industries.

Shanghai Qifuqing Material Technology PVPP-R is a cross-linked polymer that is polymerized from vinyl pyrrolidone monomer under specific conditions and is insoluble in water, strong acids, strong bases and general organic solvents.

Luctoman® is a special grade of Guar Gum, specifically developed for the Pharmaceutical industry. Guar Gum is a natural vegetable polymer, and it is obtained by refining and pulverizing the endosperm of the Guar seed - “Cyamopsis Tetragonoloba”. The use of Guar Gum as a Pharmaceutical aid has increased significantly over the last few years. The material has been successfully used as a tablet binding and disintegrating agent; in peptic ulcer therapy; jelly formulations; bulk laxatives; appetite depressants; emulsions and suspensions; lotions and creams, and as a viscosifying and stabilizing agent. Some Pharmaceutical formulators have produced pharmaceutically elegant and therapeutically efficient products, using Guar Gum as an aid, while others have not taken advantage of this versatile gum’s unique properties.

Sidley Chemical COA-LH 11 is a disintegrant to prevent the tablet crack and for direct compression.

Golden-Shell Pharmaceutical HIIGH-DENSITY CHITOSAN is a non-toxic and odorless.It is a off-white or slight yellow powder. Soluble in acid,and insoluble in water,base or normal organic solutions.

Golden-Shell Pharmaceutical SPECIAL MOLECULAR WEIGHT CHITOSAN is a non-toxic and odorless.It is a off-white or slight yellow powder. Soluble in acid,and insoluble in water,base or normal organic solutions.

Sidley Chemical COA-LH 22 is a normal disinterating property, used while no need of strong cohesive force.

Shanghai Qifuqing Material Technology PVPP-F is a cross-linked polymer that is polymerized from vinyl pyrrolidone monomer under specific conditions and is insoluble in water, strong acids, strong bases and general organic solvents.

Sidley Chemical COA-LH 21 is a disintegrant and adhesive to tablet by wet granulation.

Jiaozuo Zhongwei Special Products Pharmaceutical Pharmaceutical PVPP (Crospovidone Type A) is hygroscopic, insoluble in water and all other common solvents, but it swells rapidly in aqueous solution without any gel forms.