Knowde Enhanced TDS
Identification & Functionality+
Features & Benefits+
Applications & Uses+
- Soothing, moisturizing, anti-aging, restructuring and touch care
- Face, body, hair, sun and make-up care
- Care for all ages (from baby to mature skin), all types of skin and hair
- Gel, emulsion, gel-cream, lotion, foaming
pH stability: 2.0 to 10.0
Soluble in water, glycerin, butylene glycol, 20% ethanol solution
Thermostability: incorporate in the aqueous phase, either hot or cold, before or after preparing the emulsion for the emulsified forms.
Regulatory & Compliance+
Technical Details & Test Data+
Renowned for being a universal and multifunctional reference in cosmetic industry, Fucogel® owns both key active and sensory properties to easily and quickly access skin well-being. Easy to formulate, melting hair and skin needs, suitable for all types of formulas and applications, comfort and softness booster, Fucogel® is also distinguished for its large performance: short-term soothing, moisturizing, anti-aging, restructuring and touching agent. Fucogel® owes its biological effectiveness from its affinity for fucose receptors in the skin but also from its unique ability to modulate neuronal sensitivity through the ASIC pathway.
Every day, external stimuli, such as climate, pollution or chemicals cause irritation in skin and even more excessive reactions in fragile and sensitive skin. The sensations of pain and tingling involved are the witnesses of a cutaneous neurogenic inflammation. This reaction follows the release of Substance P (a neuromediator) mediated by the activation of different sensitivity receptors such as TRPV (Transient Receptor Potential Vanilloid) or ASIC (Acid-Sensing Ion Channel).
▪ Inhibition of neurogenic inflammation through ASIC signaling pathway
To describe the mode of action of Fucogel® a unique keratinocyte / neuron cell model was developed with Pr. Misery (University of Brest, France), a world reference in neurodermatology. A new tool to test active ingredient using lactic acid in vitro, a help to understand cellular mechanism involved in stinging test: an example using a bacterial polysaccharide (Fucogel®), Sakka M, Leschiera R, Le Gall-Ianotto C, Gouin O, L'herondelle K, Buscaglia P, Mignen O, Philbé JL, Saguet T, Carré JL, Misery L, Lebonvallet N - Experimental Dermatology, 2018.
Fucogel® significantly inhibits the activation of the ASIC pathway, shown by a 25% decrease of the lactic acid-induced release of Substance P. By limiting neuronal hyper-reactivity, Fucogel® relieves from neurogenic inflammation and stinging sensations
▪ Immediate neuro-soothing activity
In vivo study on volunteers with sensitive and reactive skin. One application of FUCOGEL® at 3% (or 0.3% FUCOGEL® POWDER) vs. Placebo on the nasolabial fold after lactic acid aggression. Soothing effect evaluation after 5 minutes (stinging test). Only 5 minutes after application, Fucogel® has a soothing effect on irritated and hypersensitive skin by decreasing the tingling sensation.
Fucogel® proves to be a soothing reference in neurocosmetics for sensitive and reactive skin. It restores immediately wellbeing and comfort.
In vivo study on volunteers. Application on the forearm of FUCOGEL® vs. hyaluronic acid (1% polysaccharide in water). Measurement of the hydration by N.M.R. before and after application (1h, 3h, 8h).
Ex vivo study on explants incubated in a Hoescht / fluorescent Neoglycoproteins (Fuco-proteins) medium during 90 min. Observation of the attached fucose Neoglycoproteins by epifluorescence microscopy.
Fucogel® shows a progressive and prolonged moisturizing effect. Its effect complements that of hyaluronic acid.
Keratinocytes possess on their surface some receptors involved in cellular communication and the activation of many physiological reactions. These receptors, called lectins, have a particular affinity for glycans such as fucose.
▪ Detection of fucose receptors in the epidermis
Fluorescence visualization of protein binding: demonstration of strong presence of fucose receptors in the epidermis
Thus, the cosmetic contribution of fucose-rich polysaccharide like Fucogel® makes it possible to modulate various reactions and synthesis within the skin as the one of sirtuin-1, loricrin and involucrin for anti-aging and restructuring effect.
▪ Stimulation of sirtuins-1,"youth proteins"
Sirtuins-1 are key markers of cell longevity, also called "youth proteins", because of their essential role in the control of physiological processes including DNA repair, resistance to oxidative stress and cell death. Nevertheless, age and external aggressions significantly affect their synthesis, accelerating premature aging.
Ex vivo study on explants treated topically with FUCOGEL® at 5% (or 0.5% FUCOGEL® POWDER) vs. Placebo. Quantization of sirtuins-1 by immunolabeling at D8.
Thanks to its sirtuin-1 stimulating action, Fucogel® helps to fight against aging, promotes cell longevity and consequently the stimulation of physiological processes controlled by sirtuins.
Sirtuins-1 play a key role in the promotion of epidermal differentiation. Thus, stimulating the synthesis of sirtuins-1 also helps to regenerate the barrier function. Involucrin and loricrin are proteins in the upper layers of epidermis, markers of epidermal differentiation.
▪ Stimulation of epidermal renewal
Ex vivo study on explants treated topically with FUCOGEL® at 2% and 5% (or 0.2 and 0.5% FUCOGEL® POWDER) vs. Placebo. Quantization of the loricrin and involucrin by immunolabeling at D8.
Fucogel® activates cell renewal, a capacity demonstrated through the stimulation of loricrin and involucrin expression. The cell renewal is a function which slows down with age but which nonetheless remains essential for a "young appearance" of the skin. In sensitive skin, restoring the quality of the skin barrier allows to limit the appearance of sensations of tightness, irritation and discomfort. As a result, Fucogel® confirms its benefits for sensitive and fragile skins.
Touch - Improvement of softness
In vivo studies by 15 experts on the effect and texture of a cream containing FUCOGEL® at 3, 5, 7 and 10% (or 0.3, 0.5, 0.7 and 1% FUCOGEL® POWDER) vs. Placebo.
- Easy to spread
- "Enriches" touch of aqueous formula (e.g. : lotion)
- No sticky and shiny effect
- Increases soft touch of formula
- Offers gliding to formula
Fucogel® offers a universal emotional experience through softness triggering comfort, pleasure and well-being. Fucogel® is an active ingredient perfectly suitable for producing all types of cosmetic formulations combining effectiveness and sensory properties.
▪ Coating effect for damaged hair
Ex vivo study on hair fibers denaturing in H2 O2 . Application of FUCOGEL® at 3% (or 0.3% FUCOGEL® POWDER) vs. Control and observation of hair fibers before and after rinsing. Visual analysis and scoring from 5 (damaged hair) to 1 (healthy hair) according to roughness, detached scales. Microscopic analysis.
Fucogel® decreases the surface irregularities and smoothes hair fiber, in leave-on and rinse-off conditions.
Neuro-soothing activity of Fucogel® benefits for sensitive or dry scalp, irritated by dandruff condition or chemicals used in hair dye.
Packaging & Availability+
Storage & Handling+